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RAPIDOMICS was a pilot study of rapid trio\u2010based (biological parents and neonate) ES for 25 neonates with a suspected genetic condition at the BC Women's Hospital NICU. As part of RAPIDOMICS, we explored parents' motivations and concerns regarding ES of their child, uptake of IFs for themselves, and rates of anxiety and depression at the time of pre\u2010test genetic counseling via administration of the Generalized Anxiety Disorder Assessment 7 and Patient Health Questionnaire 8. These findings were compared to those from the Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) study (outpatient trio\u2010based GWS) that includes pediatric patients with suspected genetic disease (with an average age of 10\u00a0years). Parents in RAPIDOMICS were more likely to identify \u201cdiagnosis\u201d as their primary motivation to pursue GWS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011), less likely to identify \u201cno concerns\u201d (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), and less likely to opt in to receive IFs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) than parents in CAUSES. Rates of depression and anxiety in both groups were higher relative to the general population. We present novel findings regarding the similarities and differences in parental opinions and decisions of these cohorts.<\/jats:p>","DOI":"10.1002\/jgc4.1074","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:46:25Z","timestamp":1546296385000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Genetic counseling considerations with rapid genome\u2010wide sequencing in a neonatal intensive care unit"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-1736","authenticated-orcid":false,"given":"Emma E.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Medical Genetics University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christ\u00e8le","family":"du Souich","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia Vancouver BC Canada"},{"name":"BC Children\u2019s Hospital Research Institute Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Dragojlovic","sequence":"additional","affiliation":[{"name":"Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"CAUSES Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"RAPIDOMICS Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-1314","authenticated-orcid":false,"given":"Alison M.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia Vancouver BC Canada"},{"name":"BC Children\u2019s Hospital Research Institute Vancouver BC Canada"},{"name":"BC Women\u2019s Health Research Institute Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.942626"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2252"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36706"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12829"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103144"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-012-0921-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atg.2015.02.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.226"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.410"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-017-0247-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0105-6"},{"key":"e_1_2_8_13_1","unstructured":"Government of Canada Statistics Canada.2016Census a. 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