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This study analyzed factors that may impact decision\u2010making surrounding management for increased breast cancer risk. Women with a PV in a moderate penetrance gene associated with increased risk for breast cancer were identified from an institutional database. Semi\u2010structured, qualitative interviews were conducted to analyze decision\u2010making factors. Themes were developed using deductive codes based on previous literature and inductive codes based on interviewee responses. The 16 participants (mean age\u00a0=\u00a055.9\u00a0years) included 12 women with a breast cancer diagnosis. Six women (37.5%) chose bilateral mastectomy (BM), and 10 women (62.5%) chose surveillance as management. Of the 12 women with a personal history of breast cancer, four chose to have BM (33.3%). Two women without a personal history of breast cancer chose to have BM (50.0%). Transcriptions revealed seven comprehensive themes, as well as themes unique to affected and unaffected women (Cohen's kappa\u00a0=\u00a00.80). Physician opinion was the only factor present in all interviews reported to influence risk management decision\u2010making. Several themes were consistent with prior <jats:italic>BRCA1\/BRCA2<\/jats:italic> research (family history, risk perception, sibling influence, and physician opinions). Autonomy and insurance\/finances were also important factors to participants. There were certain differences in decision\u2010making factors between affected and unaffected women, such as partner influence. Results indicate an opportunity for providers to engage their patients in a decision\u2010making process.<\/jats:p>","DOI":"10.1002\/jgc4.1220","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T21:01:02Z","timestamp":1580763662000},"page":"960-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors that impact risk management decisions among women with pathogenic variants in moderate penetrance genes associated with hereditary breast cancer"],"prefix":"10.1002","volume":"29","author":[{"given":"Melissa","family":"Napoli","sequence":"first","affiliation":[{"name":"Division of Human Genetics Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"},{"name":"College of Medicine University of Cincinnati Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology University of Cincinnati Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Hopper","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Widmeyer","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Aetna. 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