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Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry <jats:italic>BRCA1\/2<\/jats:italic> mutations. The objective of the UPTAKE study was to explore rates and predictors of risk\u2010reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious <jats:italic>BRCA1\/2<\/jats:italic> mutation. We recruited 100 Latina women with deleterious <jats:italic>BRCA1\/2<\/jats:italic> mutations from community hospitals, academic health systems, community, and advocacy organizations. Women completed interviews in Spanish or English. We obtained copies of genetic test reports for participants who provided signed medical release. After performing threefold cross\u2010validation LASSO for variable selection, we used multiple logistic regression to identify demographic and clinical predictors of BSO. Among 100 participants, 68 had undergone BSO at the time of interview. Of these 68, 35 were US\u2010born (61% of all US\u2010born participants) and 33 were not (77% of the non\u2010US\u2010born participants). Among Latinas with <jats:italic>BRCA1\/2<\/jats:italic> mutations, older age (p\u00a0=\u00a00.004), personal history of breast cancer (p\u00a0=\u00a00.003), higher income (p\u00a0=\u00a00.002), and not having a full\u2010time job (p\u00a0=\u00a00.027) were identified as variables significantly associated with uptake of BSO. Results suggest a high rate of uptake of risk\u2010reducing BSO among a sample of Latinas with <jats:italic>BRCA1\/2<\/jats:italic> mutations living in the US. We document factors associated with BSO uptake in a diverse sample of women. Relevant to genetic counseling, our findings identify possible targets for supporting Latinas\u2019 decision\u2010making about BSO following receipt of a positive <jats:italic>BRCA1\/2<\/jats:italic> test.<\/jats:p>","DOI":"10.1002\/jgc4.1322","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T17:49:58Z","timestamp":1601747398000},"page":"383-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>BRCA1\/2<\/i> mutations and risk\u2010reducing bilateral salpingo\u2010oophorectomy among Latinas: The UPTAKE study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-7076","authenticated-orcid":false,"given":"Filipa","family":"Lynce","sequence":"first","affiliation":[{"name":"Lombardi Comprehensive Cancer Center and Fisher Center for Hereditary Cancer and Clinical Genomics Research Georgetown University Washington DC 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Research Georgetown University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Friedman","sequence":"additional","affiliation":[{"name":"Force \u2013 Facing Our Risk of Cancer Empowered Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Dutil","sequence":"additional","affiliation":[{"name":"Cancer Biology Division Ponce Research Institute Ponce Health Sciences University Ponce PR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeina","family":"Nahleh","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Florida Weston FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Campos","sequence":"additional","affiliation":[{"name":"Nueva Vida Alexandria VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charit\u00e9","family":"Ricker","sequence":"additional","affiliation":[{"name":"University of Southern California Keck School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Virginia Cancer Specialists Arlington VA USA"},{"name":"US Oncology Network Virginia VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelima","family":"Denduluri","sequence":"additional","affiliation":[{"name":"Virginia Cancer Specialists Arlington VA USA"},{"name":"US Oncology Network Virginia VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-4759","authenticated-orcid":false,"given":"Jaeil","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Bioinformatics and Biomathematics Georgetown University Washington DC 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