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PRS have been shown to accurately predict women's breast cancer risk and are likely to be incorporated into personalized breast cancer risk management programs. However, there are few studies investigating the individual impact of receiving a breast cancer PRS. Existing studies have not demonstrated significant changes in perceived risk or risk management behaviors after receipt of polygenic risk information. The aim of this qualitative study was to explore how women with a family history of breast cancer construct breast cancer risk perceptions after receipt of a breast cancer PRS. Unaffected women with a family history of breast cancer who had not previously received genetic counseling regarding their breast cancer risk were invited to participate in this study. In\u2010depth, semi\u2010structured interviews were conducted with 20 women who attended a familial cancer clinic in the Australian states of Victoria and Tasmania. Data were analyzed using an inductive thematic approach. Women's lived experience played a significant role in the construction and maintenance of their breast cancer risk perception. Women's pre\u2010existing risk perceptions were informed by their family history and their knowledge that breast cancer is a multifactorial disease. Knowing that breast cancer is a multifactorial disease enabled most women to integrate genetic information with their pre\u2010existing notions of risk. Women reported that the information they received was consistent with their existing notions of personal risk and screening advice. Therefore, the PRS did not lead to a change in perceived risk or risk management behaviors for most women. The results of this study provide insight into how polygenic risk information is integrated with pre\u2010existing notions of risk, which will inform its implementation into clinical practice.<\/jats:p>","DOI":"10.1002\/jgc4.1384","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T06:25:53Z","timestamp":1611123953000},"page":"849-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Influence of lived experience on risk perception among women who received a breast cancer polygenic risk score: \u2018Another piece of the pie\u2019"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-3833","authenticated-orcid":false,"given":"Amanda M.","family":"Willis","sequence":"first","affiliation":[{"name":"Psychosocial Research Group Prince of Wales Clinical School UNSW Australia Sydney Australia"},{"name":"The Kinghorn Cancer Centre and Cancer Division Garvan Institute of Medical Research Darlinghurst Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Psychosocial Research Group Prince of Wales Clinical School UNSW Australia Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Meiser","sequence":"additional","affiliation":[{"name":"Psychosocial Research Group Prince of Wales Clinical School UNSW Australia Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"James","sequence":"additional","affiliation":[{"name":"Parkville Familial Cancer Centre Peter MacCallum Cancer Centre and the Royal Melbourne Hospital Melbourne Victoria Australia"},{"name":"The Peter MacCallum Cancer Center and The Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy L.","family":"Ballinger","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre and Cancer Division Garvan Institute of Medical Research Darlinghurst Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre and Cancer Division Garvan Institute of Medical Research Darlinghurst Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane","family":"Yanes","sequence":"additional","affiliation":[{"name":"Psychosocial Research Group Prince of Wales Clinical School UNSW Australia Sydney Australia"},{"name":"The University of Queensland Diamantina Institute, Dermatology Research Centre The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Anne","family":"Young","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre and Cancer Division Garvan Institute of Medical Research Darlinghurst Australia"},{"name":"Parkville Familial Cancer Centre Peter MacCallum Cancer Centre and the Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"314","article-title":"Breast cancer worry and mammography use by women with and without a family history in a population\u2010based sample","volume":"12","author":"Andersen M. 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