{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:54:56Z","timestamp":1792479296562,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> pathogenic variant carriers have a high lifetime risk of developing breast and ovarian malignancies. Given the risks and significant ramifications of undergoing risk\u2010reducing surgeries, many pathogenic variant carriers unaffected by cancer (previvors) struggle with family planning and reproductive decision making. The objective of this study was to determine the attitudes and practices of <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> pathogenic variant carriers with respect to family planning decision making. A cross\u2010sectional survey was conducted of <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> previvors at four Northeastern medical centers. The survey was administered electronically via email using REDCap. The survey included demographic information as well as questions about genetic testing, prophylactic surgeries, family planning, and partnering. Data were analyzed with Fisher's exact tests and <jats:italic>t<\/jats:italic> tests. The survey was completed by 139 of 422 <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> pathogenic variant carriers (response rate 33%). Thirteen were excluded from analysis due to self\u2010reported cancer history. Of the remaining 126, 21 (16.7%) were male and 105 (83.3%) were female. Female participants &lt;35\u00a0years old at the time of genetic testing were significantly more likely than those 35 or greater to report feeling urgency to have a family after finding out about their <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> pathogenic variant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Younger women also reported their genetic status had a stronger impact on their romantic relationships (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029). Men were significantly more likely to report that they felt no urgency to have a family compared to women (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Our study reflects the complex decision making for previvors and the intricacies of family planning in this population. Providers can use this knowledge as a guide to counsel patients about reproductive options.<\/jats:p>","DOI":"10.1002\/jgc4.1423","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T18:01:00Z","timestamp":1619546460000},"page":"1570-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Family planning in carriers of <i>BRCA1<\/i> and <i>BRCA2<\/i> pathogenic variants"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-4887","authenticated-orcid":false,"given":"Jessica M.","family":"Haddad","sequence":"first","affiliation":[{"name":"Department of Obstetrics\u2010Gynecology, Women and Infants' Hospital Cancer Genetics and Prevention Program and The Breast Health Center Program in Women's Oncology The Warren Alpert Medical School of Brown University Providence RI 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A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Obstetrics\u2010Gynecology, Women and Infants' Hospital Cancer Genetics and Prevention Program and The Breast Health Center Program in Women's Oncology The Warren Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Hofstatter","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Prevention Program Yale Cancer Center Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disha","family":"Dalela","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Prevention Program Yale Cancer Center Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hartford Healthcare Cancer Institute Hartford CT 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