{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:19:26Z","timestamp":1747149566282,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our work evaluates the contributions of a genetics clinic visit in assessing patients\u2019 risk of hereditary cancers and in meeting National Cancer Comprehensive Network (NCCN) criteria for genetic testing. We reviewed the electronic health records (EHR) of 56 women seen for medical care in our healthcare system who were subsequently seen in the Adult Genetics Clinic. We searched for all personal or family cancer history available in either free\u2010text or structured form within the EHR prior to the genetics visit. For each patient, we then compared the aggregate data with the pedigree information obtained at the Genetics Clinic visit for first\u2010, second\u2010, and third\u2010degree relatives. During the genetics clinic visit, the number of relatives with cancer diagnoses doubled from 121 to 235, and for 17 of 56 (30%) of patients, family histories changed one or more NCCN criteria. For 39\/56 (70%) of patients, the family history in the EHR was not changed during the genetics clinic visit. Of 56 women referred to the genetics clinic, 45 (80%) met NCCN guidelines for testing, 40 women underwent genetic testing, and 9 of 40 (23%) tested were positive for a Likely Pathogenic or Pathogenic (LP\/P) variant. This study of 56 women quantitatively demonstrates the value of a genetics clinic visit by improved identification of key family history components.<\/jats:p>","DOI":"10.1002\/jgc4.1425","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T02:57:05Z","timestamp":1619060225000},"page":"1591-1597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of a genetics clinic evaluation in identifying women at risk for hereditary breast\u2010ovarian cancer syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Jesse C.","family":"Hinshaw","sequence":"first","affiliation":[{"name":"University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lue\u2010Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Institute Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Brimm","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Medicine (General Internal Medicine) University of Washington School of Medicine Seattle WA USA"},{"name":"Brotman Baty Institute for Precision Medicine University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-7855","authenticated-orcid":false,"given":"Fuki M.","family":"Hisama","sequence":"additional","affiliation":[{"name":"Brotman Baty Institute for Precision Medicine University of Washington Seattle WA USA"},{"name":"Department of Medicine (Medical Genetics) University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003562"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01631"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.6314"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-019-0652-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222709"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.147"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.18.00072"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.2369"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.12483"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328332dca3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1153"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07549-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.2140"},{"key":"e_1_2_10_16_1","unstructured":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines).Genetic\/Familial High\u2010Risk Assessment: Breast and OvarianVersion 3.2019. Retrieved fromhttps:\/\/www.nccn.org[registered users only access]"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8430"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0712-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa152"},{"key":"e_1_2_10_20_1","unstructured":"Polubriaginof F. Tatonetti N. P. &Vawdrey D. K.(2015).An assessment of family history information captured in an electronic health record.American Medical Informatics Association AnnualSymposiumProceedings Archive eCollection:2035\u20132042."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e3182310bcf"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2004.30401.x"},{"key":"e_1_2_10_23_1","unstructured":"Sin M. McGuinness J. E. Trivedi M. S. Vanegas A. Silverman T. B. Crew K. D. &Kukafka R.(2018).Automatic genetic risk assessment calculation using breast cancer family history data from the EHR compared to self\u2010report.American Medical Informatics Association Annual Symposium Proceedings Archive. eCollection:970\u2010978."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2019.1612702"},{"key":"e_1_2_10_25_1","unstructured":"Wang Y. Wang L. Rastegar\u2010Mojarad M. Liu S. Shen F. &Liu H.(2017).Systematic analysis of free\u2010text family history in electronic health record.American Medical Informatics Association Joint Summits Translational Science. eCollection:104\u2013113."}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.1425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.1425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.1425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:05:08Z","timestamp":1693191908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.1425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/jgc4.1425"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.1425","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"type":"print","value":"1059-7700"},{"type":"electronic","value":"1573-3599"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"2020-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}