{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:27:03Z","timestamp":1780446423773,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with a personal history of breast or ovarian cancer who previously had <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> testing now have the opportunity for additional genetic risk information through multi\u2010gene panel testing. However, little is known about women's receptivity to further contact and uptake of genetic counseling and updated genetic testing. Utilizing a clinic database to identify potential participants, we prospectively contacted women in the United States with a personal and\/or family history of breast or ovarian cancer who had negative <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> testing, which was performed primarily between 2011 and 2018. Eligible and interested participants were scheduled for a genetic counseling appointment to discuss updated genetic testing using a multi\u2010gene panel. We attempted to contact 455 participants, screened 203 (45%), and 103 (23%) completed a pre\u2010test genetic counseling visit to discuss updated testing. Of these, 88 participants had updated multi\u2010gene panel testing. Participants had an average age of 59\u00a0years, and most (78%) had breast cancer with an average age of 45 at diagnosis. The majority (97%) of participants were white. Of participants who underwent panel testing, 13% (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) had at least one pathogenic variant identified. Most participants (86%) had an out\u2010of\u2010pocket cost of $100 or less for their panel. There is a sizable population of women with a personal and\/or family history of breast or ovarian cancer and negative <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> test results who would qualify for updated multi\u2010gene panel testing. In our study, 59% of those reached who were eligible completed a pre\u2010test genetic counseling visit. Clinics could consider an outreach program to offer genetic counseling and updated genetic testing. Supports for this type of effort may include coordinators and genetic counseling assistants and an available database with patients\u2019 contact information and prior genetic test results. Updated testing allows women more information about their risk and may expand the value of genetic counseling.<\/jats:p>","DOI":"10.1002\/jgc4.1513","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:44:03Z","timestamp":1632779043000},"page":"470-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uptake of genetic counseling and multi\u2010gene panel testing among women in the Intermountain West with previous negative <i>BRCA1<\/i> and <i>BRCA2<\/i> results contacted for updated testing"],"prefix":"10.1002","volume":"31","author":[{"given":"Ryan","family":"Mooney","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Espinel","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Elrick","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"},{"name":"Department of Communication University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kohlmann","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Kaphingst","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"},{"name":"Department of Communication University of Utah  Salt 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