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The WISDOM trial is testing a model of risk\u2010based breast cancer screening that integrates genomic (nine genes and polygenic risk) and other risk factors. In the context of an embedded Ethical, Legal, and Social Implications (ELSI) study of WISDOM, we conducted qualitative interviews at two timepoints post\u2010result disclosure with 22 <jats:italic>ATM<\/jats:italic> and <jats:italic>CHEK2<\/jats:italic> carriers. Results disclosure and interview recordings were transcribed and analyzed using a grounded theory analysis framework. We found that participants minimized the significance of their results in comparison to <jats:italic>BRCA<\/jats:italic>; were surprised but not alarmed by the results in the absence of family history; did not fundamentally change their perception of their breast cancer risk despite the new genomic information; exhibited variable responses to WISDOM\u2019s screening and risk reduction recommendations; and shared test results with family but did not strongly encourage cascade testing. Participants viewed the results as having limited utility and responded accordingly. Our study offers important insights into how genetic test results for moderate\u2010risk genes are received, understood, and acted upon in population screening context.<\/jats:p>","DOI":"10.1002\/jgc4.1617","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T15:44:21Z","timestamp":1658763861000},"page":"1421-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A qualitative study of unaffected <scp><i>ATM<\/i><\/scp> and <scp><i>CHEK2<\/i><\/scp> carriers: How participants make meaning of \u2018moderate risk\u2019 genetic results in a population breast cancer screening trial"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-3487","authenticated-orcid":false,"given":"Jennifer Elyse","family":"James","sequence":"first","affiliation":[{"name":"Institute for Health and Aging University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Riddle","sequence":"additional","affiliation":[{"name":"Department of Humanities and Social Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikaella","family":"Caruncho","sequence":"additional","affiliation":[{"name":"Department of Humanities and Social Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Ann","family":"Koenig","sequence":"additional","affiliation":[{"name":"Institute for Health and Aging University of California, San Francisco  San Francisco California USA"},{"name":"Department of Humanities and Social Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galen","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Humanities and Social Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S111394"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.181"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2021.01.001"},{"key":"e_1_2_10_5_1","unstructured":"Campbell M.(2019).Navigating the uncertainty: Experiences of patients with pathogenic or likely pathogenic variants in ATM and CHEK2[Thesis]. 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