{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:45:05Z","timestamp":1784709905864,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several models of genetic counseling have been proposed to tackle the increasing volume of individuals requiring access to <jats:italic>BRCA<\/jats:italic> testing. Few data are available on patient experience and retention of information with nurse\u2010driven genetic counseling. We evaluated the experience and retention of information in women with an uninformative <jats:italic>BRCA<\/jats:italic> test result and who were not considered at high risk due to their personal\/family history of cancer who underwent geneticist\u2010supervised nurse\u2010driven genetic counseling and who received their test result by phone. Women who received an uninformative <jats:italic>BRCA<\/jats:italic> test result between May 2017 and September 2019 were administered a questionnaire exploring experience with genetic counseling and retention of information provided. Of 366 eligible women, 299 (273 breast cancer patients and 26 women without breast cancer) completed the interview. Overall, 280 women (93.6%) positively valued their experience with genetic counseling and 287 (96.0%) considered it helpful with 57.5% of them feeling reassured for themselves and their family. Information on the clinical implications of the test result was correctly retained and women acted accordingly. Overall, 252 women (87.8%) accurately reported their test result as normal\/negative. Only 67 (22.4%) recognized that despite a normal <jats:italic>BRCA<\/jats:italic> test result, a low probability of a hereditary syndrome remains. Most women showed a poor ability to estimate cancer risk in <jats:italic>BRCA<\/jats:italic> mutation carriers and in the general population. Geneticist\u2010supervised nurse\u2010driven genetic counseling process for women with uninformative <jats:italic>BRCA<\/jats:italic> test result is associated with a positive patient experience and an adequate retention of information concerning the management of their personal and familial cancer risk. The design and implementation of nurse\u2010driven genetic counseling models may contribute to efficient and timely access to <jats:italic>BRCA<\/jats:italic> genetic testing.<\/jats:p>","DOI":"10.1002\/jgc4.1630","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T15:13:46Z","timestamp":1661786026000},"page":"140-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Experience with a nurse\u2010driven genetic counseling pathway of Italian women with uninformative <scp><i>BRCA<\/i><\/scp> test result"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-4579","authenticated-orcid":false,"given":"Eva","family":"Blondeaux","sequence":"first","affiliation":[{"name":"Breast Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Lambertini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine University of Genova  Genoa Italy"},{"name":"Department of Medical Oncology, Clinica di Oncologia Medica IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Buzzatti","sequence":"additional","affiliation":[{"name":"Breast Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Hereditary Cancer Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Bruzzone","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Unit IRCCS Ospedale Policlinico San Martino  Genoa 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Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Varesco","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Bonelli","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit IRCCS Ospedale Policlinico San Martino  Genoa 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