{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:31:02Z","timestamp":1789569062573,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010237","name":"National Society of Genetic Counselors","doi-asserted-by":"publisher","award":["Jane Engelberg Memorial Fellowship"],"award-info":[{"award-number":["Jane Engelberg Memorial Fellowship"]}],"id":[{"id":"10.13039\/100010237","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While genetic testing for hereditary breast and ovarian cancer syndrome (HBOC) is well\u2010established in the field of medicine, family members' uptake of cascade genetic testing for known familial pathogenic variants remains low. Probands often become responsible for initiating familial communication about their testing results, and barriers to communication may include difficulty in conveying information to relatives and a lack of communication resources for probands' use. In this study, we tested a two\u2010minute animated digital message (ADM) intervention guided by the Health Belief Model (HBM) in an unselected sample to determine hypothetical individual perceptions of susceptibility and severity and behavioral intention to act on the information provided in the ADM. We recruited genetic testing na\u00efve adults from the United States with no personal history of cancer through Amazon Mechanical Turk to participate in this study. Participants were presented a hypothetical scenario describing a relative's recent HBOC diagnosis, viewed the ADM, and answered a questionnaire assessing participants' perception of the HBM constructs in relation to the hypothetical scenario and participants' intentions to pursue cascade genetic testing, talk to a healthcare professional, or talk to family members after ADM viewing. Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0373) largely perceived HBOC as serious and believed that they could benefit from the information provided by genetic testing; 76% hypothetically intended to pursue genetic testing at a cost of $100 or less, and 90% intended to either pursue testing or talk to a healthcare provider or family members. This feasibility study in an unaffected population could mimic the experience of distant\/less\u2010engaged relatives in HBOC families after receiving unexpected information about cascade genetic testing. Most participants demonstrated behavioral intention toward cascade testing, at a rate higher than literature would suggest is typical in high\u2010risk families, indicating that a theory\u2010supported, simple to use intervention may be useful in clinical practice.<\/jats:p>","DOI":"10.1002\/jgc4.1656","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T10:13:41Z","timestamp":1669371221000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>BRCAShare<\/scp>\u2014Assessment of an animated digital message for intrafamilial communication of pathogenic variant positive test results: A feasibility study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-7853","authenticated-orcid":false,"given":"Amber M.","family":"Aeilts","sequence":"first","affiliation":[{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly R.","family":"Hovick","sequence":"additional","affiliation":[{"name":"School of Communication The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Byrne","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail B.","family":"Shoben","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigha","family":"Senter","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1345"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.014"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1882"},{"key":"e_1_2_13_5_1","unstructured":"Centers for Disease Control and Prevention. (2019).2019 behavioral risk factor surveillance system questionnaire [Measurement instrument].https:\/\/www.cdc.gov\/brfss\/questionnaires\/pdf\u2010ques\/2019\u2010BRFSS\u2010Questionnaire\u2010508.pdf"},{"key":"e_1_2_13_6_1","author":"Centers for Disease Control and Protection","year":"2014","journal-title":"Tier 1 Genomics Applications and their Importance to Public Health"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010021815\u2010093623"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010010\u20109296\u2010y"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002457"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002296"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010009\u20109271\u20107"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100164\u2010x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010014\u20109720\u20109"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.10005"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.075176"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010013\u20109592\u20104"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191111425856"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119057840.ch68"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010008\u20109200\u20101"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.52"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010010\u20109377\u2010y"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.483"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7112"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1307"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000144014.91237.a1"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010004\u20107992\u20101"},{"key":"e_1_2_13_27_1","volume-title":"Family environment scale manual","author":"Moos R.","year":"1994"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010017\u20104246\u20100"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30104"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010018\u20100083\u20105"},{"key":"e_1_2_13_31_1","unstructured":"Pew Research Center. (2021).Pew Research Center Internet and Broadband Fact Sheet.http:\/\/www.pewresearch.org\/fact\u2010tank\/2017\/01\/12\/evolution\u2010of\u2010technology\/"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.09.035"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.2307\/3348967"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.07.141"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201020\u20100141"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.014"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2018.03.030"},{"key":"e_1_2_13_38_1","volume-title":"A guide to genetic counseling","author":"Uhlmann W. R.","year":"2009"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010010\u20109385\u2010y"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010018\u20100226\u20108"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.1656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.1656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.1656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:00:22Z","timestamp":1692673222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.1656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/jgc4.1656"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.1656","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]},"assertion":[{"value":"2021-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}