{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:15:47Z","timestamp":1784999747606,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Research suggests variants of uncertain significance (VUSs) present a variety of challenges for genetic counselors (GCs), nongenetics clinicians, and patients. Multigene cancer panels reveal more VUSs than single gene testing as a result of the increase in the number of genes being tested. This study surveyed 87 clinical cancer GCs involved with direct patient care and 19 laboratory GCs who provide guidance to clinicians regarding genetic test results about their attitudes on various options for the reporting of VUSs by laboratories for broad multigene cancer panels. Independent samples <jats:italic>t<\/jats:italic>\u2010tests were utilized to compare the two groups. Based on a six\u2010point Likert\u2010type scale (1\u00a0=\u00a0Strongly Disagree to 6\u00a0=\u00a0Strongly Agree), clinical cancer GCs (M\u00a0=\u00a05.4; SD\u00a0=\u00a00.8) and laboratory GCs (M\u00a0=\u00a05.2; SD\u00a0=\u00a00.9) agreed overall that VUSs should be reported (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.44; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.21). When asked about specific reporting options, both clinical cancer GCs (M\u00a0=\u00a01.9; SD\u00a0=\u00a01.1) and laboratory GCs (M\u00a0=\u00a02.1; SD\u00a0=\u00a01.4) disagreed that VUSs should be reported only for genes related to the indication for testing (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.50; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.17). Overall, most GCs felt clinicians should not choose whether VUSs should be reported on genetic test results, with clinical cancer GCs (M\u00a0=\u00a01.9; SD\u00a0=\u00a01.3) feeling more strongly against it than laboratory GCs (M\u00a0=\u00a03.1; SD\u00a0=\u00a01.4; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.88). Generally, GCs were more in favor of VUSs not being reported for population\u2010based screening, with laboratory GCs (M\u00a0=\u00a04.7; SD\u00a0=\u00a00.8) agreeing more with that practice than clinical cancer GCs (M\u00a0=\u00a03.7; SD\u00a0=\u00a01.4; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.80). Both clinical cancer GCs (M\u00a0=\u00a04.1; SD\u00a0=\u00a01.2) and laboratory GCs (M\u00a0=\u00a03.9; SD\u00a0=\u00a01.2) agreed additional guidelines on how to approach VUSs in clinical practice should be developed (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.54; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.17). While most GCs supported the reporting of VUSs overall, our analyses suggest clinical cancer and laboratory GCs may have different attitudes toward specific VUS\u2010related reporting options. Further research is needed to elucidate GC preferences to help inform best practices for the reporting of VUSs. The development of additional standardized guidelines on how to approach VUSs would further support clinical practice.<\/jats:p>","DOI":"10.1002\/jgc4.1680","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T05:20:39Z","timestamp":1675747239000},"page":"706-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-5522","authenticated-orcid":false,"given":"Emmeline Y.","family":"Chang","sequence":"first","affiliation":[{"name":"USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"},{"name":"Department of Human Genetics and Genetic Counseling Keck Graduate Institute  Claremont California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-2623","authenticated-orcid":false,"given":"Ilana","family":"Solomon","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-3507","authenticated-orcid":false,"given":"Julie O.","family":"Culver","sequence":"additional","affiliation":[{"name":"USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-4001","authenticated-orcid":false,"given":"Nicholas","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Genetic Counseling Keck Graduate Institute  Claremont California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-5079","authenticated-orcid":false,"given":"Jacob G.","family":"Comeaux","sequence":"additional","affiliation":[{"name":"USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-8724","authenticated-orcid":false,"given":"Caryn","family":"Lerman","sequence":"additional","affiliation":[{"name":"USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-1165","authenticated-orcid":false,"given":"Emily A.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Genetic Counseling Keck Graduate Institute  Claremont California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-5612","authenticated-orcid":false,"given":"Tali","family":"Ekstein","sequence":"additional","affiliation":[{"name":"Clinical Consultation Services, Invitae  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010020\u201000456\u20106"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.4316"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1374"},{"key":"e_1_2_13_5_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12097"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33357"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100391\u2010z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.01.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.9403"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000666"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000391"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.94"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100099\u20102"},{"key":"e_1_2_13_15_1","unstructured":"Informed Consent for All Color Tests. 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