{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:00:22Z","timestamp":1773442822573,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01363"],"award-info":[{"award-number":["PI16\/01363"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical and familial factors predict psychological distress after genetic testing for cancer susceptibility. However, the contribution of an individual's psychological background to such distress is unclear. This study aims to analyze the psychological impact of genetic testing and to identify the profile of individuals at higher risk. This is a longitudinal multicenter study of individuals undergoing genetic testing for cancer susceptibility. Demographic, clinical, genetic, familial, and psychological (personality types, cancer worry) characteristics were assessed by validated questionnaires the day of genetic testing. Distress, uncertainty, and positive experience perception (MICRA scale) were evaluated at the results disclosure visit, and 3 and 12\u2009months afterwards. Multivariate analysis was performed. A total of 714 individuals were included. A high neuroticism score, high baseline cancer worry, and a positive genetic test result were independently associated with higher psychological impact (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.05). The highest risk profile (10% of the cohort) included women with high level of neuroticism and a positive result. Uncertainty was mainly associated with a high level of neuroticism, regardless of the genetic test result. A holistic approach to personalized germline genetic counseling should include the assessment of personality dimensions.<\/jats:p>","DOI":"10.1002\/jgc4.1687","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T11:28:41Z","timestamp":1675769321000},"page":"778-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of psychological background in cancer susceptibility genetic testing distress: It is not only about a positive result"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-5998","authenticated-orcid":false,"given":"Adri\u00e0","family":"L\u00f3pez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Hereditary Cancer Genetics Group Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"},{"name":"Medical Oncology Department Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Genetic and Microbiology Department Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Villacampa","sequence":"additional","affiliation":[{"name":"Oncology Data Science (ODysSey) Group VHIO  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Salinas","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Duran i Reynals Hospital, Catalan Institute of Oncology IDIBELL  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Grau","sequence":"additional","affiliation":[{"name":"Genetic and Microbiology Department Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Hereditary Cancer Program, Duran i Reynals Hospital, Catalan Institute of Oncology IDIBELL  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Darder","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Josep Trueta University Hospital, Catalan Institute of Oncology IDIBGI  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Genetics Group Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"},{"name":"Medical Oncology Department Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ares","family":"Solanes","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Germans Trias i Pujol Hospital Catalan Institute of Oncology  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Velasco","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Josep Trueta University Hospital, Catalan Institute of Oncology IDIBGI  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maite","family":"Torres","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Genetics Group Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Munt\u00e9","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Duran i Reynals Hospital, Catalan Institute of Oncology IDIBELL  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Duran i Reynals Hospital, Catalan Institute of Oncology IDIBELL  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Torres\u2010Esquius","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Genetics Group Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noem\u00ed","family":"Tuset","sequence":"additional","affiliation":[{"name":"Genetic Counseling Unit Arnau de Vilanova University Hospital  Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orland","family":"Diez","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Genetics Group Area of Clinical and Molecular Genetics, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conxi","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Molecular Diagnosis Laboratory Catalan Institute of Oncology  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Brunet","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Duran i Reynals Hospital, Catalan Institute of Oncology IDIBELL  Barcelona Spain"},{"name":"Medical Sciences Dpt. 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