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We developed an educational booklet about the psychiatric manifestations of 22q11DS and assessed its utility among parents of children with the condition. First, six parents of individuals with 22q11DS completed cognitive interviews to review an established generic booklet about the genetics of psychiatric conditions\u2014and to suggest 22q11DS\u2010specific adaptations. We used these suggestions to develop a novel booklet specific to psychiatric conditions and 22q1DS. Then, before and 1\u2010month after reading the novel 22q11DS\u2010specific online booklet, 73 parents of children with 22q11DS (with\/without psychiatric conditions) completed validated scales (measuring empowerment, stigma, intolerance of uncertainty), an adapted version of a scale measuring worry about their child developing psychiatric illness, and purpose\u2010designed items assessing perceptions of understanding of 22q11DS and mental illness, confidence in recognizing early signs, etc. After reading the 22q11DS online booklet, participants' feelings of empowerment increased (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), while feelings of worry about their child developing psychiatric illness decreased (<jats:italic>p<\/jats:italic>\u2009=\u20090.05), and they reported better understanding 22q11DS and mental illness, and increased confidence in recognizing early warning signs. There is potential benefit in broadly distributing this educational booklet to parents of children with 22q11DS.<\/jats:p>","DOI":"10.1002\/jgc4.1779","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T04:39:51Z","timestamp":1693629591000},"page":"720-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and evaluation of an educational resource for parents of children with 22q11.2 deletion syndrome about the psychiatric manifestations of the condition"],"prefix":"10.1002","volume":"33","author":[{"given":"Kayla","family":"Blankenship","sequence":"first","affiliation":[{"name":"University of South Carolina Genetic Counseling Program  Columbia South Carolina USA"},{"name":"University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Chieffo","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Slomp","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolan","family":"Batallones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloise","family":"Prijoles","sequence":"additional","affiliation":[{"name":"Greenwood Genetic Center, Columbia  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Hill\u2010Chapman","sequence":"additional","affiliation":[{"name":"University of South Carolina Genetic Counseling Program  Columbia South Carolina USA"},{"name":"Department of Psychology Francis Marion University  Florence South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-7055","authenticated-orcid":false,"given":"Jehannine","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12457"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.039"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/poq\/nfm006"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.22684"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2016.02.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010022\u201003289\u20107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.179"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.014"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1460"},{"key":"e_1_2_13_11_1","first-page":"171","article-title":"Teaching about cystic fibrosis carrier screening by using written and video information","volume":"57","author":"Clayton E. 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