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This study aimed to evaluate genetic counselor experiences disclosing SCAs positive prenatal screening or testing results and genetic counselor\u2010reported parental questions regarding sex, gender, and sexual orientation. Forty\u2010eight prenatal genetic counselors completed the survey. When asked to quantify their experiences, 97.9% of counselors reported disclosing a SCAs positive screen result within the previous year, and 81.3% disclosed a diagnostic result. Of those counselors, 53.8% reported always or often receiving parental questions about sex, 33% always or often about gender, and 25% always or often regarding sexual orientation. Counselors were asked to share examples of parental questions following a positive screen or diagnostic testing for SCAs. Parental questions were stratified by karyotype and content analysis revealed questions about the fetus' sex, anatomy, reproduction, being cisgender, gender expression, behavior, being transgender, and sexual orientation. The examples of parental questions provided by genetic counselors suggested some parents may have misconceptions about the intersection of SCAs with sex, gender, and sexual orientation following prenatal screening or diagnostic testing. The majority of counselors (83.3%) agreed to some extent that they desired further education on responding to parental questions about SCAs. Findings from this research suggest a need for genetic counseling strategies that accurately and respectfully discuss SCAs in the context of sex, gender, and sexual orientation with prenatal patients.<\/jats:p>","DOI":"10.1002\/jgc4.1897","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T23:34:12Z","timestamp":1712964852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Parental questions about sex chromosome aneuploidies regarding sex, gender, and sexual orientation as reported by genetic counselors in a prenatal setting"],"prefix":"10.1002","volume":"34","author":[{"given":"Sarah","family":"Burzynski","sequence":"first","affiliation":[{"name":"MS Genetic Counseling Program University of North Carolina Greensboro  Greensboro North Carolina USA"},{"name":"Wellstar Health System  Marietta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Leonard","sequence":"additional","affiliation":[{"name":"Roberts Individualized Medical Genetics Center, Division of Human Genetics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna Plamondon","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Maine Medical Center  Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-5799","authenticated-orcid":false,"given":"Lauren E.","family":"Doyle","sequence":"additional","affiliation":[{"name":"MS Genetic Counseling Program University of North Carolina Greensboro  Greensboro North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-9503","authenticated-orcid":false,"given":"Rachel","family":"Mills","sequence":"additional","affiliation":[{"name":"MS Genetic Counseling Program University of North Carolina Greensboro  Greensboro North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"American Psychological Association. 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