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In the Gitxsan community of 5500, an estimated 1 in 125 individuals are affected, primarily due to the novel pathogenic variant p.V205M in <jats:italic>KCNQ1<\/jats:italic>. Over the past decade, more than 800 Gitxsan individuals received genetic testing and counseling for LQTS through a community\u2010based study. Despite the substantial research characterizing the biological underpinnings of LQTS, there are few studies exploring the lived experiences of families with LQTS, especially those of Indigenous peoples. The goal of this study was to gain a greater understanding of the impact of the genetic confirmation of LQTS in this community, and the impact the condition has on individuals, their families, and the community. A qualitative study was developed in consultation with a local research advisory board and a Talking Circle, a traditional Indigenous format for discussion, was held. Four people who belonged to the same kindred group attended the Talking Circle. This article presents the multigenerational impact that LQTS and genetic diagnosis have through the reflections of one Gitxsan family. LQTS affects identity and family relationships, including those between parents and children, siblings, and even extended family members. Laughter and humor played an important part in coping. The role of family relationships for this Gitxsan family was seen to be critical in managing an LQTS diagnosis. This multigenerational perspective provides key insights into family structure and dynamics which can inform genetic counseling and clinical care. As cultural safety is experienced and therefore defined by the person receiving services, listening to the perspectives and preferences of Indigenous peoples is essential to the delivery of culturally informed care.<\/jats:p>","DOI":"10.1002\/jgc4.1927","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T23:59:11Z","timestamp":1719446351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The multigenerational impact of long QT syndrome: A Gitxsan perspective"],"prefix":"10.1002","volume":"34","author":[{"given":"Lee\u2010Anna","family":"Huisman","sequence":"first","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheridan","family":"Martin","sequence":"additional","affiliation":[{"name":"Gitanmaax  Hazelton British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Ewasiuk","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"McAdam","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u2019sana","family":"Wood Lynes\u2010Ford","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Victoria  Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"McCormick","sequence":"additional","affiliation":[{"name":"Department of Education Thompson River University  Kamloops British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-0880","authenticated-orcid":false,"given":"Laura","family":"Arbour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"},{"name":"Division of Medical Sciences University of Victoria  Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043132"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000294277"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010008\u20109167\u2010y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/gim.0b013e31817c6b19"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1562"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010023\u201001642\u20101"},{"key":"e_1_2_12_8_1","unstructured":"BC Treaty Commission. 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