{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:10:37Z","timestamp":1784819437634,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Risk assessment models that are applied to assess the lifetime risk of cancer and pathogenic variant risk are more commonly used in Western populations. Using these models, without validation, for non\u2010Western populations has been questioned. This study aimed to evaluate the use and consistency of the Manchester Scoring System as a risk assessment model for the Omani population. A retrospective, file\u2010based analysis was performed on breast cancer patients seen in a genomics department over a two\u2010year period. Personal cancer history and family history were used to analyze the Manchester scores of 409 breast and\/or cancer patients. The results show that, overall, the Manchester scores were low. If this risk assessment model had been used to determine eligibility for a priori service and genetic testing decisions, 12 <jats:italic>BRCA<\/jats:italic> pathogenic cases would have been missed. At this time, the Manchester Scoring System does not seem to be the best risk assessment model for use in the Omani population, unless the eligibility threshold of \u22656 is used, which could provide a better sensitivity for the Omani population. We propose using concepts of the Manchester Scoring model to create a scoring system that is more suitable for the Omani and Arabic population.<\/jats:p>","DOI":"10.1002\/jgc4.1939","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:53:48Z","timestamp":1718704428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Manchester Scoring System for predicting <i>BRCA1\/2<\/i> mutations underperforms in Arabic Omani breast cancer patients"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-3517","authenticated-orcid":false,"given":"Chantel","family":"van Wyk","sequence":"first","affiliation":[{"name":"Genomics Department Sultan Qaboos Comprehensive Cancer Care and Research Center  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Al\u2010Sayegh","sequence":"additional","affiliation":[{"name":"Research Laboratories Department Sultan Qaboos Comprehensive Cancer Care and Research Center  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara I.","family":"Al\u2010Kiyumi","sequence":"additional","affiliation":[{"name":"Genomics Department Sultan Qaboos Comprehensive Cancer Care and Research Center  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaida S.","family":"Al\u2010Mamari","sequence":"additional","affiliation":[{"name":"Genomics Department Sultan Qaboos Comprehensive Cancer Care and Research Center  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer A.","family":"Al Saegh","sequence":"additional","affiliation":[{"name":"Genomics Department Sultan Qaboos Comprehensive Cancer Care and Research Center  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010043976"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2003.10.001"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.056556"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603306"},{"key":"e_1_2_12_6_1","volume-title":"StatPearls","author":"Casaubon J. 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