{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:22:57Z","timestamp":1790349777793,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advances in our understanding of the genetic landscape of hereditary breast and ovarian cancer (HBOC) have led to the clinical adoption of multi\u2010gene panel testing. Panel testing introduces new sources of genetic uncertainty secondary to the inclusion of moderate\u2010 and low\u2010penetrance genes, as well as the increased likelihood of identifying a variant of uncertain significance (VUS). This cross\u2010sectional study explored the post\u2010test psychological functioning of women who underwent multi\u2010gene panel testing for HBOC susceptibility genes. Two hundred and ninety\u2010five women who underwent panel testing within the previous 2\u2009years completed a study questionnaire to measure levels of cancer\u2010related and genetic testing\u2010related distress using the Impact of Events Scale (IES) and the Multidimensional Impact of Cancer Risk Assessment (MICRA), respectively. Multiple regression analyses were conducted to evaluate the relationship between genetic test results and levels of psychological distress captured by the IES and MICRA. In this cohort, a pathogenic variant (PV) was identified in 41 (14%) of participants, and 77 (26%) participants were found to have a VUS. In the multi\u2010variate model, higher mean levels of genetic testing\u2010related distress were observed in individuals with a PV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) or a VUS (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) compared to those with a negative result. Furthermore, participants with a PV in a moderate\u2010penetrance gene were found to have higher levels of genetic testing\u2010related distress compared to those with a PV in a high\u2010risk gene (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Overall, participants were highly satisfied with their genetic testing experience, with 92% of individuals reporting they would recommend testing to others. Our findings highlight differences in psychological outcomes based on both variant pathogenicity and gene penetrance, which contribute to our understanding of the impact of panel testing and sources of both cancer\u2010related and genetic testing\u2010related distress secondary to testing.<\/jats:p>","DOI":"10.1002\/jgc4.1940","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T03:30:03Z","timestamp":1721791803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Psychological distress following multi\u2010gene panel testing for hereditary breast and ovarian cancer risk"],"prefix":"10.1002","volume":"34","author":[{"given":"Lindsay","family":"Carlsson","sequence":"first","affiliation":[{"name":"Phase 1 Drug Development Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Lawrence S. 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