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Despite the many different approaches (somatic or germline testing, targeted gene or genome sequencing), the implicated individuals are confronted with situations that may intersect and that are interesting to compare. No study has identified and analyzed the available works on these new practices in pediatric oncology. The aim of this narrative literature review was to describe the ethical and psychological perspectives of children with cancer, parents, and healthcare professionals when genetic or genomic testing is proposed as part of the cancer management. Eighteen articles met the inclusion criteria and were comprehensively coded using MAXQDA. Their analysis showed that concerning the subjective implications of genetic and genomic testing, the areas of ambivalence (desire of treatment, desire for knowledge, uncertainty, and guilt) reported by patients and their parents seem to mirror the healthcare professionals' concerns. The ethical and psychological issues about predisposition testing, long discussed in the context of hereditary retinoblastoma and Li\u2010Fraumeni syndrome, represent a useful starting point for a wider discussion of a genetic and genomic testing pathway in pediatric oncology more broadly.<\/jats:p>","DOI":"10.1002\/jgc4.1955","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T03:49:37Z","timestamp":1722311377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Narrative review on ethical and psychological issues raised by genetic and genomic testing in pediatric oncology care"],"prefix":"10.1002","volume":"34","author":[{"given":"Marion","family":"Droin\u2010Mollard","sequence":"first","affiliation":[{"name":"UF de Psychologie et Psychiatrie de Liaison et d'Urgences, DMU Psychiatrie et Addictologie, et D\u00e9partement de G\u00e9n\u00e9tique, APHP, Centre\u2010Universit\u00e9s de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Hervouet","sequence":"additional","affiliation":[{"name":"IRIS Institut de Recherche Interdisciplinaire Sur les Enjeux Sociaux (UMR 8156 CNRS \u2013 997 INSERM \u2013 EHESS \u2013 UPSN), Campus Condorcet  Aubervilliers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Lahlou\u2010Lafor\u00eat","sequence":"additional","affiliation":[{"name":"UF de Psychologie et Psychiatrie de Liaison et d'Urgences, DMU Psychiatrie et Addictologie, et D\u00e9partement de G\u00e9n\u00e9tique, APHP, Centre\u2010Universit\u00e9s de Paris  Paris France"},{"name":"Consultation Multidisciplinaire d'oncog\u00e9n\u00e9tique Des Cancers Rares Hopital europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-9379","authenticated-orcid":false,"given":"Sandrine","family":"de Montgolfier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil  Cr\u00e9teil France"},{"name":"Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de l'Information M\u00e9dicale, ISSPAM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Agence de Biom\u00e9decine. 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