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Qualitative studies are necessary to investigate the psychological state of individuals who underwent predictive testing for HD, because the psychosocial impact on noncarriers remains unclarified in Japan. Herein, we elucidated the psychosocial impact on the noncarriers for HD and the role of genetic counseling for predictive testing and follow\u2010up after testing by examining their experiences with predictive testing. We conducted semi\u2010structured interviews with eight individuals participating in this study. Interview data were transcribed verbatim and evaluated according to thematic analysis. As a result, 4 themes were generated from 21 categories of 46 codes: (1) Diversity of perceptions concerning the test results, (2) Views on life as a noncarrier, (3) Changes in feelings toward and relationships with family members, and (4) Sharing information within the family. After receiving the negative results, the noncarriers felt not only relief but also surprise, doubt, relief from tension, and regret. It was shown that noncarriers felt survivor's guilt toward many unspecified individuals, which was not only a sense of guilt but also a sense of mission or responsibility. Additionally, they conducted altruistic behavior as members of their family and society, that may be related to the Japanese collectivism. Some participants were concerned about sharing information with their siblings. Noncarriers for HD can experience complex psychological states, and Japanese people who prefer high\u2010context communication may find it difficult to express their feelings and thoughts. It is important to understand their true feelings before and after the predictive genetic testing, reconsider the impact of being a noncarrier and whether it is a burden for them from both subjective and objective perspectives, and conduct long\u2010term follow\u2010up as needed.<\/jats:p>","DOI":"10.1002\/jgc4.1981","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T05:15:27Z","timestamp":1728105327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychosocial impact on individuals who received negative test results from predictive testing for Huntington's disease: An\u00a0exploratory qualitative study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7723-9188","authenticated-orcid":false,"given":"Harumo","family":"Osawa","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Medical Ethics Kyoto University School of Public Health  Kyoto Japan"},{"name":"Clinical and Molecular Genetics Center Hamamatsu University School of Medicine  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Genetic Medicine and Services National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Kyoto University School of Public Health  Kyoto Japan"},{"name":"Clinical Genetics Unit Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Torishima","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Kyoto University School of Public Health  Kyoto Japan"},{"name":"Clinical Genetics Unit Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Haruyama","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Medical Ethics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Kyoto University School of Public Health  Kyoto Japan"},{"name":"Clinical Genetics Unit Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Medical Ethics Kyoto University School of Public Health  Kyoto Japan"},{"name":"Department of Genomic Medicine Kyoto University School of Public Health  Kyoto Japan"},{"name":"Clinical Genetics Unit Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063Oa"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14780887.2020.1769238"},{"key":"e_1_2_13_4_1","first-page":"11","article-title":"Concept and definition of Survivor's guilt: A review","volume":"17","author":"Domen I.","year":"2009","journal-title":"Bulletin of Traumatic Stress Studies"},{"key":"e_1_2_13_5_1","volume-title":"Genetic counselling manual revised","author":"Fukushima Y.","year":"2016"},{"key":"e_1_2_13_6_1","volume-title":"Understanding cultural differences: Germans, French and Americans","author":"Hall E.","year":"1990"},{"issue":"1","key":"e_1_2_13_7_1","first-page":"61","article-title":"Guide to the diagnosis, treatment, and recuperation of Huntington's disease","volume":"37","author":"Hasegawa K.","year":"2020","journal-title":"Neurological Therapeutics"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420417"},{"key":"e_1_2_13_9_1","volume-title":"Genetic testing protocol for Huntington's disease","author":"Huntington's Disease Society of America","year":"2016"},{"key":"e_1_2_13_10_1","volume-title":"Huntington's Disease (intractable disease 8)","author":"Japan Intractable Diseases Information Centre","year":"2023"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3180653c5a"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102296\u20106\u201038"},{"key":"e_1_2_13_13_1","unstructured":"Matsuda I. &Fukushima Y.(Eds.). (2001).A review of ethical issues in genetic medicine. [in Japanese]."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1519"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn\u2010001608"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.5630\/jans.40.23"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn\u2010001771"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD\u2010200402"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90585\u2010e"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1245"},{"key":"e_1_2_13_21_1","volume-title":"A guide to genetic counselling","author":"Uhlmann W. 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