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This study aimed to determine if genetic testing revealing a pathogenic variant associated with a significantly higher lifetime risk of breast cancer would influence decisions regarding chest surgery type. The investigators hypothesized that <jats:italic>BRCA1\/2<\/jats:italic> pathogenic variant carrier status would influence gender\u2010diverse individuals to elect a more invasive surgery to address increased cancer risk. Of 26 transgender and gender\u2010diverse individuals without a history of chest surgery, 23.1% stated they would likely elect a more invasive surgery type based on positive genetic testing results while, of 17 individuals with a previous history of chest reconstruction, 52.9% stated it was unlikely that genetic testing would have altered their surgical decision\u2010making. These results suggest that health care providers should counsel transgender patients about the utility of genetic testing prior to gender\u2010affirming chest reconstruction.<\/jats:p>","DOI":"10.1002\/jgc4.70003","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:52:10Z","timestamp":1746190330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gender\u2010affirming chest surgery decisions in response to hypothetical <i>BRCA1\/2<\/i> genetic testing"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2278-8719","authenticated-orcid":false,"given":"Taylor I.","family":"Gray","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Hollings Cancer Center Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Safer","sequence":"additional","affiliation":[{"name":"Center for Transgender Medicine and Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Zaretsky","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1374"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1172"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003479"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1652"},{"issue":"1","key":"e_1_2_12_6_1","first-page":"e30","article-title":"Cancer screening rates among transgender adults: Cross\u2010sectional analysis of primary care data","volume":"65","author":"Kiran T.","year":"2019","journal-title":"Canadian Family Physician"},{"issue":"11","key":"e_1_2_12_7_1","first-page":"645","article-title":"Caring for transgender and gender\u2010diverse persons: What clinicians should know","volume":"98","author":"Klein D. 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