{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:00Z","timestamp":1753869420875,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["n\/a Intramural Research Program"],"award-info":[{"award-number":["n\/a Intramural Research Program"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cascade genetic testing involves testing at\u2010risk relatives for a gene variant identified in the family to tailor clinical management. The first person in a family identified with a pathogenic or likely pathogenic variant is the proband. We aimed to determine proband characteristics associated with cascade testing for the <jats:italic>CDH1<\/jats:italic> gastric and breast cancer susceptibility gene. Cascade genetic testing proportions in 100 <jats:italic>CDH1<\/jats:italic> families were analyzed. Overall, 57% (248\/427) of proband's first\u2010degree relatives (FDR) and 31% (135\/436) of second\u2010degree relatives (SDR) underwent testing. Proband characteristics associated with higher mean proportions of genetic testing in FDR included male sex (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and personal history of gastric cancer (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). A difference was also detected in mean uptake proportions by proband's race\/ethnicity. White probands had higher mean proportions of SDR tested (40%) compared to Asian (9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and Black (5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) probands. Testing proportions in FDR and SDR increased with the length of time from proband's <jats:italic>CDH1<\/jats:italic> diagnosis (FDR <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, SDR <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Age when proband was tested, personal history of breast cancer, and variant in another cancer gene did not influence testing uptake in FDR and SDR. Proband characteristics associated with higher <jats:italic>CDH1<\/jats:italic> cascade genetic testing proportions include male sex, White race\/ethnicity, and a personal history of gastric cancer. Probands who are female, Asian, Black, and those without a personal history of gastric cancer may require tailored support facilitating <jats:italic>CDH1<\/jats:italic> cascade testing in at\u2010risk relatives. Additional studies are needed to gain a deeper understanding of how proband characteristics influence the uptake of cascade genetic testing for cancer risk.<\/jats:p>","DOI":"10.1002\/jgc4.70011","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:57:49Z","timestamp":1746061069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between proband characteristics and <scp><i>CDH1<\/i><\/scp> cascade genetic testing uptake in at\u2010risk relatives"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-846X","authenticated-orcid":false,"given":"Grace\u2010Ann","family":"Fasaye","sequence":"first","affiliation":[{"name":"Genetics Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Calzone","sequence":"additional","affiliation":[{"name":"Genetics Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Travis","sequence":"additional","affiliation":[{"name":"Genetics Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber F.","family":"Gallanis","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Gamble","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"volume-title":"Cancer Facts and Figures\u00a02024","year":"2024","author":"American Cancer Society","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00057\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040925"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9316"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30219\u20109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/109065703322537241"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010023\u201009304\u2010y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy147"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10868"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010016\u20109889\u20101"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100825\u20102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010013\u20109592\u20104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.2820"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2007.0037"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01238"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1012025"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.11.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.5.573"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8543"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010004\u20107991\u20102"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.06.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2019.03.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010018\u20100089\u2010z"},{"key":"e_1_2_8_26_1","unstructured":"NCCN. (2024).Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Genetic\/Familial High\u2010Risk Assessment: Colorectal Endometrial and Gastric V.3.2024. \u00a9 National Comprehensive Cancer Network Inc. 202X. All rights reserved. Accessed 11\/14\/2024. To view the most recent and complete version of the guideline go online toNCCN.org."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2017.1630"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1208"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10852"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.867226"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368745"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.12.e84"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet\u20102019\u2010105991"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:02:01Z","timestamp":1746601321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jgc4.70011"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70011","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"type":"print","value":"1059-7700"},{"type":"electronic","value":"1573-3599"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"assertion":[{"value":"2024-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70011"}}