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By statistically combining data from individual studies, a meta\u2010analysis can provide a precise estimate of an intervention's overall effect. The aim of this quantitative meta\u2010analysis was to assess the efficacy of genetic counseling for familial colorectal cancer and to explore characteristics that might influence the direction or magnitude of the relationship between the intervention and the outcome. We conducted an electronic search of literature published until March 2024. This identified 3150 articles, 30 of which met the inclusion criteria. Effect size parameters and sample sizes for all variables in each study were included. Results showed that genetic counseling has an overall statistically significant effect size of small magnitude (<jats:italic>d<\/jats:italic>\u2009=\u20090.234). Results indicate that genetic counseling is effective for affective (<jats:italic>d<\/jats:italic>\u2009=\u20090.162), cognitive (<jats:italic>d<\/jats:italic>\u2009=\u20090.298), and behavioral outcomes (<jats:italic>d<\/jats:italic>\u2009=\u20090.539); for individuals with a personal and\/or family history; whether testing is diagnostic or predictive; and, with the exception of uncertain\/uninformative results (4 studies), regardless of the testing results. Also, clinical\/research teams that included a genetic counselor generated a significantly larger effect compared to teams without a genetic counselor. Our analysis showed that genetic counseling is effective for familial colorectal cancer. These results should encourage theoretical analyses and empirical studies exploring the process and rationale of genetic counseling from a more programmatic perspective.<\/jats:p>","DOI":"10.1002\/jgc4.70046","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:54:34Z","timestamp":1748951674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The efficacy of genetic counseling for familial colorectal cancer: A meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Andrada","family":"Ciuc\u0103","sequence":"first","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Clancy","sequence":"additional","affiliation":[{"name":"Division of Evolution and Genomic Sciences, School of Biological Science University of Manchester  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Pintea","sequence":"additional","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-5076","authenticated-orcid":false,"given":"Ramona","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Science University of Manchester  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100215(19990412)81:2<214::aid\u2010ijc8>3.0.co;2\u2010l"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7762"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.051581"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010013\u20109628\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:fame.0000039863.89137.f9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100082\u2010y"},{"key":"e_1_2_12_8_1","unstructured":"Baron R. 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