{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:26:26Z","timestamp":1761719186920,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This cross\u2010sectional study evaluated the knowledge and understanding of basic genetic concepts, as well as the acceptance of screening and preventive measures, among 100 adult patients and\/or parents of children with primary congenital glaucoma (PCG) at King Khalid Eye Specialist Hospital. The study population included 36 males and 64 females. Following genetic counseling sessions for participants who had received genetic test results, an assessment was conducted using structured telephone interviews. Parents and adult patients generally demonstrated an understanding of autosomal recessive conditions: 93% recognized the increased genetic risk associated with consanguinity, and 87% were aware that an unaffected individual may be a carrier of the mutation. However, approximately one\u2010third still had difficulty understanding or recalling recurrence risks. There was moderate\u2010to\u2010high motivation among participants to engage in preventive actions. While 61% supported prenatal genetic screening (PGS), 78% expressed willingness to use preimplantation genetic diagnosis (PGD) to avoid having an affected child; reinforcing the need to fast\u2010track a congenital glaucoma prevention program. Such an initiative would facilitate the identification of carriers prior to marriage, enabling informed decision\u2010making regarding pregnancy management.<\/jats:p>","DOI":"10.1002\/jgc4.70087","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T06:05:53Z","timestamp":1757657153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Congenital glaucoma prevention program\u2014Evaluation of patient knowledge and acceptance of genetic screening"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7014-9738","authenticated-orcid":false,"given":"Areej","family":"Alizary","sequence":"first","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulwahab","family":"AlTheeb","sequence":"additional","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2746-0784","authenticated-orcid":false,"given":"Syed","family":"Hameed","sequence":"additional","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5816-3895","authenticated-orcid":false,"given":"Bashaer","family":"Almadani","sequence":"additional","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4032-7024","authenticated-orcid":false,"given":"Shereen","family":"Abualkhair","sequence":"additional","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-2920","authenticated-orcid":false,"given":"Leyla Ali","family":"Aljasim","sequence":"additional","affiliation":[{"name":"King Khalid Eye Specialist Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_16_2_1","first-page":"2911","article-title":"Screening of CYP1B1 and LTBP2 genes in Saudi families with primary congenital glaucoma: Genotype\u2010phenotype correlation","volume":"17","author":"Abu\u2010Amero K. K.","year":"2011","journal-title":"Molecular Vision"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1960"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256\u20104947.2022.29"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjopt.sjopt_154_23"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.18060\/24666"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2019.10.002"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2015.12.002"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201056121\u20102"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055102920987455"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2015.09.009"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2023.03.018"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100076\u20109"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmab013"},{"issue":"1","key":"e_1_2_16_15_1","first-page":"12","article-title":"Genetic epidemiology of primary congenital glaucoma in the world. Part I","volume":"20","author":"Oganezova Z.","year":"2023","journal-title":"Rossi\u012dski\u012d Oftal'mologicheski\u012d Zhurnal"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277\u20109536(91)90078\u2010q"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010020\u20100627\u20107"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14636778.2020.1805305"},{"key":"e_1_2_16_19_1","unstructured":"Salim F. Hockings E. Caffery S. Lahnstein L. R. Hubbard T. &Middleton R.(2019).A public dialogue on genomic medicine: Time for a new social contract? Genomics England London Event."},{"issue":"1","key":"e_1_2_16_20_1","first-page":"1","article-title":"Legalization and Islamic bioethical perspectives on prenatal diagnosis and advanced uses of pre\u2010implantation genetic diagnosis in Saudi Arabia","volume":"4","author":"Sultan H.","year":"2013","journal-title":"Journal of Clinical Research and Bioethics"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.20421"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010022\u201001082\u20101"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100090\u20109"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:15:19Z","timestamp":1761696919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jgc4.70087"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70087","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"type":"print","value":"1059-7700"},{"type":"electronic","value":"1573-3599"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70087"}}