{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:43:08Z","timestamp":1791294188497,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report pregnancy termination rates following a variety of fetal diagnoses and determine which factors may influence this decision. We conducted a retrospective chart review of pregnancies diagnosed with a genetic abnormality at a single institution from January 2012 to April 2023. The type of diagnosis, termination status, and thirteen demographic factors were collected. The primary outcome assessed was whether or not an individual terminated the pregnancy. Data analysis consisted of multivariable logistic regression. Of the 2120 patients who underwent prenatal diagnostic testing, 332 received a fetal diagnosis and met inclusion criteria. The overall termination rate was 61.5% (204\/332). Compared with sex chromosome abnormalities, trisomy 18\/trisomy 13\/triploidy (adjusted odds ratio [aOR] 6.35, 95% Confidence Interval [CI] 1.93\u201320.90) and trisomy 21 (aOR 4.39, 95% CI 1.58\u201312.24) had higher odds to terminate, while likely benign copy number variants (CNVs) (aOR 0.17, 95% CI 0.03\u20130.99) had lower odds to terminate. Black paternal race and ethnicity had a lower termination rate (aOR 0.08, 95% CI 0.03\u20130.23) compared to White counterparts. Earlier gestational age at diagnosis was associated with higher odds of termination (aOR 0.84, 95% CI 0.78\u20130.90). This study demonstrates that termination rates varied by type of fetal diagnosis. Paternal race and ethnicity, as well as gestational age at diagnosis, also impacted the decision to terminate.<\/jats:p>","DOI":"10.1002\/jgc4.70099","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T05:39:42Z","timestamp":1755322782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating pregnancy termination rates for fetal chromosome and single gene disorders"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7456-2934","authenticated-orcid":false,"given":"Madeline J.","family":"Herman","sequence":"first","affiliation":[{"name":"Ann B. Barshinger Cancer Institute Penn Medicine Lancaster General Health  Lancaster Pennsylvania USA"},{"name":"Rutgers University Genetic Counseling Master's Program  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily B.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kasatkin","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Heiman","sequence":"additional","affiliation":[{"name":"Rutgers University Genetic Counseling Master's Program  Piscataway New Jersey USA"},{"name":"Department of Genetics and the Human Genetics Institute of New Jersey Rutgers, the State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama P.","family":"Khan","sequence":"additional","affiliation":[{"name":"Rutgers University Genetic Counseling Master's Program  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ashkinadze","sequence":"additional","affiliation":[{"name":"Rutgers University Genetic Counseling Master's Program  Piscataway New Jersey USA"},{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000001817"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001947"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004084"},{"key":"e_1_2_13_5_1","unstructured":"American Pregnancy Association.First fetal movement: Quickening in pregnancy.https:\/\/americanpregnancy.org\/healthy\u2010pregnancy\/pregnancy\u2010health\u2010wellness\/first\u2010fetal\u2010movement"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.2005.080762"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001509"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010009\u20109275\u20103"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010022\u201000584\u20101"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2017.02.004"},{"key":"e_1_2_13_11_1","unstructured":"Dobbs v. Jackson Women's Health Organization. (2022).597 U.S. 215."},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz016"},{"key":"e_1_2_13_13_1","unstructured":"Freedom of Reproductive Choice Act P.L. (2021).c. 375."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.07.050"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010012\u20109539\u20101"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.008"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/3097821"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114391"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101754.1982.tb02000.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20103400995"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.099"},{"key":"e_1_2_13_22_1","unstructured":"Roe v. Wade. (1973).410 U.S. 113."},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1462"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.01.022"},{"key":"e_1_2_13_25_1","unstructured":"StataCorp LLC. (2021).Stata statistical software: Release 17."},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22026"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c30fb2"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010014\u20109744\u20101"},{"key":"e_1_2_13_29_1","unstructured":"United States Census Bureau. (2020).2020 DEC demographic profile: Profile of general population and housing characteristics.https:\/\/data.census.gov\/table\/DECENNIALDP2020.DP1"},{"key":"e_1_2_13_30_1","unstructured":"United States Department of Health and Human Services National Institutes of Health. (2015).Racial and ethnic categories and definitions for NIH diversity programs and for other reporting purposes (NOT\u2010OD\u201015\u2010089).https:\/\/grants.nih.gov\/grants\/guide\/notice\u2010files\/NOT\u2010OD\u201015\u2010089.html"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(07)61602\u2010x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6377.1542"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000242"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T05:39:44Z","timestamp":1755322784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jgc4.70099"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70099","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70099"}}