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A nested cross\u2010sectional online survey combining both closed\u2010 and open\u2010ended questions was used. Quantitative data included sociodemographic characteristics, family functioning as measured with the SCORE\u201015, genetic literacy (score range 0\u20134), and preferences regarding whether participants would want to be informed of a genetic risk in their family across three hypothetical scenarios (Cystic Fibrosis, Hereditary Breast and Ovarian Cancer and early\u2010onset Alzheimer's disease). These data were analyzed using descriptive and inferential statistics. Qualitative data, consisting of open\u2010ended responses on the reasons for not wanting to be informed, were analyzed inductively through reflexive thematic analysis. Of the 609 lay participants, 44 (7.2%) expressed a hypothetical preference not to be informed of a genetic risk in their family. Qualitative analysis of their responses revealed four main themes: (1) worry about anxiety and emotional distress in oneself and loved ones; (2) protection against psychological harm; (3) probability, uncertainty, and skepticism about preventive medicine; and (4) worry about stigma. These findings highlight the emotional, ethical, and social complexity behind the decision to decline genetic risk information and underscore the need for strategies to encourage and facilitate intrafamilial genetic risk communication that goes beyond education alone.<\/jats:p>","DOI":"10.1002\/jgc4.70126","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:45:37Z","timestamp":1762865137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perspectives of Italian lay persons who would decline genetic risk information: \u201cI think I'd be living in constant worry\u201d"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-9372","authenticated-orcid":false,"given":"Lea","family":"Godino","sequence":"first","affiliation":[{"name":"Medical Genetics Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Battistuzzi","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit 2 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-6668","authenticated-orcid":false,"given":"Liliana","family":"Varesco","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-3921","authenticated-orcid":false,"given":"Daniela","family":"Turchetti","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Gentili","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-3410","authenticated-orcid":false,"given":"Paolo","family":"Chiari","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-844X","authenticated-orcid":false,"given":"Alvisa","family":"Palese","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10689\u2010024\u201000379\u2010Y\/FIGURES\/2"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AMEPRE.2015.07.019"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/CGE.13529\/"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13053\u2010020\u201000151\u20100\/FIGURES\/5"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/JME.2002.001578"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13083"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJMG.B.32016"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/JLME.12115"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/02692163241234800"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gimo.2024.101896"},{"key":"e_1_2_14_13_1","doi-asserted-by":"crossref","unstructured":"Causio F. 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