{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:17:16Z","timestamp":1779365836180,"version":"3.53.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was designed to identify outcome data for non\u2010invasive prenatal testing (\n                    <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                    ) results suggestive of an atypical sex chromosome abnormality of fetal\/placental origin. A single\u2010center descriptive case series was performed between January 1, 2022 and August 1, 2024, which identified 16 cases, 11 of which completed diagnostic testing. Of those 11 cases, only 2 were found to have detectable chromosomal abnormalities of the fetus (monosomy X and mosaic monosomy X). The majority of the 9 cases without detectable fetal chromosome abnormalities cannot be assessed for the presence of confined placental mosaicism due to the lack of\n                    <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>\n                    testing; however one confirmed case was identified. While this case series is limited in size, it highlights examples that can be used by clinicians in counseling patients about possible outcomes for these atypical\n                    <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                    results. These cases also showcase the importance of pre and post\u2010test counseling, due to the complexity of results. Larger studies are needed to elucidate the mechanisms underlying these findings and to further guide patient counseling.\n                  <\/jats:p>","DOI":"10.1002\/jgc4.70138","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:58:07Z","timestamp":1762930687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcome data for non\u2010invasive prenatal testing suggestive of an atypical sex chromosome abnormality of fetal\/placental origin"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-7325","authenticated-orcid":false,"given":"Matthew","family":"Rich","sequence":"first","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts USA"},{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman Ali","family":"Jan","sequence":"additional","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts USA"},{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Fraser","sequence":"additional","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts USA"},{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Waldron","sequence":"additional","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts USA"},{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Alice","family":"Abbott","sequence":"additional","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts USA"},{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"},{"name":"UMass Memorial Medical Center  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1097\/AOG.0000000000004084","article-title":"Screening for fetal chromosomal abnormalities: ACOG practice bulletin, number 226","volume":"136","author":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins\u2014Obstetrics","year":"2020","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1448"},{"issue":"5","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/jgc4.1714","article-title":"High rates of \u201catypical\u201d single nucleotide polymorphism\u2010based noninvasive prenatal screening results among consanguineous Arab American patients: A single center retrospective study","volume":"32","author":"Ayyash M.","year":"2023","journal-title":"Journal of Genetic Counseling"},{"issue":"2","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ogc.2017.02.004","article-title":"Prenatal diagnosis: Screening and diagnostic tools","volume":"44","author":"Carlson L. 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