{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:54:32Z","timestamp":1763985272282,"version":"3.45.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014943","name":"Sarepta Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007441","name":"John Merck Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Duchenne muscular dystrophy (DMD) is a rare inherited, X\u2010linked neuromuscular disorder that leads to a progressive decline in physical mobility, muscle atrophy, and premature death. Newborn screening (NBS) offers the potential for earlier diagnosis and earlier intervention, although NBS using the creatine kinase isoenzyme (CK\u2010MM) assay may detect conditions other than DMD and lead to initial false\u2010positive results. Early Check, a voluntary supplemental newborn screening study in North Carolina, screened 16,566 newborns for DMD over nearly 3\u2009years. Parents and legal guardians of infants who received an initial false\u2010positive screen result for DMD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) were interviewed about their experiences. Data were coded in NVivo using directed content analysis. Participants described feelings of stress, shock, and concern associated with receiving the initial positive screening result, and varying levels of stress and anxiety while waiting for confirmatory genomic panel testing during the follow\u2010up period. The study genetic counselor played a critical role in sharing the initial false\u2010positive results, answering parents'\/guardians' questions, and informing them of factors other than DMD that can cause elevated CK\u2010MM levels. Despite the stressful experience of receiving a false\u2010positive result, parents\/guardians found value in participating in Early Check, as it provided knowledge about their child's health and the opportunity for earlier intervention, if needed.\n                  <\/jats:p>","DOI":"10.1002\/jgc4.70141","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:50:31Z","timestamp":1763985031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experiences of parents who receive a false\u2010positive\n                    <scp>CK<\/scp>\n                    \u2010\n                    <scp>MM<\/scp>\n                    screening for their newborn"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-5811","authenticated-orcid":false,"given":"Janice P.","family":"Tzeng","sequence":"first","affiliation":[{"name":"Center for Communication and Engagement Research RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-0216","authenticated-orcid":false,"given":"Allyson M.","family":"Corbo","sequence":"additional","affiliation":[{"name":"Center for Communication and Engagement Research RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-9277","authenticated-orcid":false,"given":"Heidi L.","family":"Cope","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-0411","authenticated-orcid":false,"given":"Emily","family":"Cheves","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-0976","authenticated-orcid":false,"given":"Sara M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Scott","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth Lincoln","family":"Boyea","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-6083","authenticated-orcid":false,"given":"Sean N.","family":"Halpin","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-7453","authenticated-orcid":false,"given":"Holly L.","family":"Peay","sequence":"additional","affiliation":[{"name":"GenOmics and Translational Research Center RTI International, Research Triangle Park  North Carolina 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