{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:02:48Z","timestamp":1789174968612,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In 2020, the UCLA Cancer Genetics service launched a point\u2010of\u2010care pilot program called GENETECA\u2122 (GENetic Education and TEsting for CAncer) in the Pancreatic Cancer Integrated Practice Unit (PancIPU) to comply with national guidelines recommending universal germline genetic testing (gGT). We present a guide for the implementation of similar models at other institutions along with the uptake and outcomes of GENETECA. Patients with pancreatic ductal adenocarcinoma (PDAC) obtaining care at UCLA Health between August 12, 2020 and January 1, 2023 were identified through electronic medical record review. Abstracted data included patient demographics and GENETECA endpoints (gGT, opted for traditional genetic counseling visit, declined, or loss to follow up). Data were analyzed using Chi\u2010squared testing for categorical variables and Wilcoxon rank\u2010sum tests for non\u2010parametric data. In 2019, prior to the implementation of GENETECA, only 9% (18\/194) of patients with PDAC seen at PancIPU had pre\u2010test counseling and gGT by cancer genetic counselors. After the implementation of GENETECA, 94% (222 out of 237) of PDAC patients were offered gGT. Approximately 80% of patients with PDAC who were offered GENETECA proceeded with testing, independent of patient age. Non\u2010English speakers were no less likely to complete GENETECA than English\u2010speaking patients, and no significant difference in completion was observed across races. Implementing this point\u2010of\u2010care, high\u2010throughput approach significantly improved compliance with national guidelines and proved to be a cost\u2010effective service delivery model. Its success has allowed us to procure additional financial and health system support to expand cancer genetic services across many other tumor\u2010site specialty clinics. Our described implementation may be used as a framework for other institutions to implement similar models.<\/jats:p>","DOI":"10.1002\/jgc4.70143","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:35:52Z","timestamp":1764329752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From the ground up: Launching\n                    <scp>GENETECA<\/scp>\n                    \u2122 (\n                    <scp>GENetic<\/scp>\n                    education and\n                    <scp>TEsting<\/scp>\n                    for\n                    <scp>CAncer<\/scp>\n                    ) a point\u2010of\u2010care cancer genetics service at an academic medical center"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-9292","authenticated-orcid":false,"given":"Daniella","family":"Kamara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Niell","family":"Swiller","sequence":"additional","affiliation":[{"name":"UCLA Health\u2010Cancer Services  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bedford","sequence":"additional","affiliation":[{"name":"UCLA Health\u2010Cancer Services  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Conlon","sequence":"additional","affiliation":[{"name":"UCLA Health\u2010Cancer Services  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramil T.","family":"Badana","sequence":"additional","affiliation":[{"name":"Department of Surgery David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aletta","family":"Deranteriassian","sequence":"additional","affiliation":[{"name":"Department of Surgery David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Siavoshi","sequence":"additional","affiliation":[{"name":"Department of Urology David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Urology David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Lester","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Surgery David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"UCLA\u2010Jonsson Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-2933","authenticated-orcid":false,"given":"Beth Y.","family":"Karlan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"UCLA\u2010Jonsson Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4236\/ajibm.2018.82013","article-title":"Improving healthcare referral system using lean six sigma","volume":"8","author":"Alkinaidri A.","year":"2018","journal-title":"American Journal of Industrial and Business Management"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001806\u2010y"},{"issue":"4","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14041059","article-title":"The feasibility of implementing mainstream germline genetic testing in routine cancer care\u2014A systematic review","volume":"14","author":"Bokker K.","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"3","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10689-021-00277-7","article-title":"Positive experiences of healthcare professionals with a mainstreaming approach of germline genetic testing for women with ovarian cancer","volume":"21","author":"Bokkers K.","year":"2022","journal-title":"Familial Cancer"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1200\/OP-24-00635","article-title":"Educational video as an alternative to pretest in\u2010person genetic counseling in candidates for Cancer genetic testing: A randomized controlled noninferiority trial","volume":"21","author":"Chavarri\u2010Guerra Y.","year":"2025","journal-title":"JCO Oncology Practice"},{"issue":"4","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/jgc4.1689","article-title":"Critical components of genomic medicine practice for non\u2010genetics healthcare professionals: Genetic counselors' perspectives and implications for medical education","volume":"32","author":"Coleman T.","year":"2023","journal-title":"Journal of Genetic Counseling"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1200\/PO.21.00409","article-title":"Mainstreaming genetic testing for epithelial ovarian cancer by oncology providers: A survey of current practice","volume":"6","author":"Czekalski M. A.","year":"2022","journal-title":"JCO Precision Oncology"},{"issue":"4","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1903387","article-title":"Maintenance olaparib for germline BRCA\u2010mutated metastatic pancreatic cancer","volume":"381","author":"Golan T.","year":"2019","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41436-020-0797-2","article-title":"Positive impact of genetic counseling assistants on genetic counseling efficiency, patient volume, and cost in a cancer genetics clinic","volume":"22","author":"Hallquist M. L.","year":"2020","journal-title":"Genetics in Medicine"},{"issue":"1","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/GCO.0000000000000920","article-title":"Genetic risk assessment in breast and gynecologic malignancies\u2010what's to know in 2024?","volume":"36","author":"Kamara D.","year":"2024","journal-title":"Current Opinion in Obstetrics and Gynecology"},{"issue":"34","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1200\/JCO.21.01604","article-title":"Overall survival results from the POLO trial: A phase III study of active maintenance olaparib versus placebo for germline BRCA\u2010mutated metastatic pancreatic cancer","volume":"40","author":"Kindler H. L.","year":"2022","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jama.2023.9526","article-title":"Germline genetic testing after cancer diagnosis","volume":"330","author":"Kurian A. W.","year":"2023","journal-title":"JAMA"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.24.00356"},{"issue":"10242","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi J. D.","year":"2020","journal-title":"The Lancet"},{"key":"e_1_2_12_16_1","unstructured":"National Society of Genetic Counselors (NSGC). (2020).Professional Status Survey 2020: Service Delivery & Access Report. Retrieved February 23 2024 fromhttps:\/\/www.nsgc.org\/Research\u2010and\u2010Publications\/Professional\u2010Status\u2010Survey\/Past\u2010Professional\u2010Status\u2010Surveys"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.1002\/jgc4.1984","article-title":"Cardiac genetic counseling services: Exploring downstream revenue in a pediatric medical center","volume":"34","author":"Olson M.","year":"2024","journal-title":"Journal of Genetic Counseling"},{"issue":"11","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1200\/OP.23.00007","article-title":"Pretest video education versus genetic counseling for patients with prostate cancer: ProGen, a multisite randomized controlled trial","volume":"19","author":"Rana H. Q.","year":"2023","journal-title":"JCO Oncology Practice"},{"issue":"3","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.6004\/jnccn.2019.0014","article-title":"NCCN guidelines insights: Pancreatic adenocarcinoma, version 1.2019: Featured updates to the NCCN guidelines","volume":"17","author":"Tempero M. A.","year":"2019","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"11","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"e1982","DOI":"10.1002\/onco.13968","article-title":"Implementation of an embedded in\u2010clinic genetic testing station to optimize germline testing for patients with pancreatic adenocarcinoma","volume":"26","author":"Walker E. J.","year":"2021","journal-title":"The Oncologist"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:35:56Z","timestamp":1764329756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jgc4.70143"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70143","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70143"}}