{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:00:34Z","timestamp":1784883634250,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["3165\u201000017B"],"award-info":[{"award-number":["3165\u201000017B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prenatal detection of mosaicism in chorionic villus sampling (CVS) poses significant challenges for genetic counseling due to difficulties in predicting fetal involvement and clinical outcomes. Even when mosaicism is confined to the placenta (CPM), there remains an elevated risk of adverse outcomes, including preterm birth and low birth weight. These uncertainties regarding diagnosis and prognosis complicate clinical decision\u2010making and may have a profound psychological impact on expectant parents. Thus, this qualitative study aimed to explore how parents experience the diagnosis and navigate pregnancy following a prenatal diagnosis of CPM. The study was conducted within Denmark's national healthcare system from January 2023 to November 2024. During this period, 14 semistructured interviews were carried out with 24 participants (10 joint interviews with both parents, four interviews with the mother only) who had received a prenatal CPM diagnosis and continued pregnancy. Interviews took place approximately 6\u2009months after birth and were analyzed using thematic analysis. Uncertainty was central to parents' experiences of CPM, varying in intensity across individuals and over time. Three overarching themes were developed to explore this uncertainty: (1)\n                    <jats:italic>Sources of uncertainty<\/jats:italic>\n                    , included the complexity of mosaicism, probabilistic risk, and ambiguous information; (2)\n                    <jats:italic>Impact of uncertainty<\/jats:italic>\n                    , reflected fears about fetal health and emotional strain on parents; and (3)\n                    <jats:italic>Managing uncertainty<\/jats:italic>\n                    , involved both problem\u2010focused strategies (e.g., information\u2010seeking) and emotion\u2010focused strategies (e.g., distancing, seeking support, and maintaining hope). Additionally, clear, empathetic communication from healthcare professionals supported parental coping, while ambiguous or inconsistent messaging intensified uncertainty. The birth of a healthy baby was a significant relief, though uncertainty and worry continued to linger for some. These findings highlighted the central role of uncertainty in parental experiences of CPM and can inform genetic counseling approaches to address this uncertainty and support adaptive coping throughout pregnancy.\n                  <\/jats:p>","DOI":"10.1002\/jgc4.70174","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:40:34Z","timestamp":1769841634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A qualitative study of parents' experiences with receiving a prenatal diagnosis of confined placental mosaicism \u2013 \u201cWe had nothing to rely on, you know?\u201d"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7694-9066","authenticated-orcid":false,"given":"Johanne","family":"Far\u00f8","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Center for Fetal Diagnostics, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-8954","authenticated-orcid":false,"given":"Simon Horsholt","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnostics, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Genetics Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Genetics Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7109-1403","authenticated-orcid":false,"given":"Ingeborg Rytter","family":"Stenstrup","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnostics, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-0393","authenticated-orcid":false,"given":"Ida","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Center for Fetal Diagnostics, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Gynaecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-5780","authenticated-orcid":false,"given":"Stina","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Center for Fetal Diagnostics, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"DEFACTUM\u2014Public Health Research, Central Denmark Region  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"American Anthropological Association. 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