{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:04:19Z","timestamp":1781006659080,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal Exome Sequencing (pES) increases the diagnostic rate for genetic disorders in pregnancies with structural abnormalities and substantially impacts parental decision\u2010making regarding pregnancy continuation or termination. Previous qualitative research on parental experiences of pES has typically been performed several months after results were returned to parents. Moreover, parental experiences of pES might be dependent on cultural aspects and country\u2010specific healthcare systems. This research therefore prospectively explores experiences of families undergoing pES in the Netherlands. Expectant parents undergoing pES because of ultrasound anomalies were invited to participate with two interviews: interview T1 after counseling for genetic testing but prior to return of results and interview T2 six\u2009 months after return of results. We translated a previously designed Australian interview script, used in similar research, to Dutch, including four open\u2010end and two multiple\u2010choice questions in addition to demographic details. An inductive content analysis approach was used for coding and analysis. Twelve families were interviewed at T1, of which five participants agreed to T2 follow\u2010up interviews. We constructed six content categories of importance: (1) Prenatal feelings of fear, uncertainty, guilt, and anxiety; (2) conflicting feelings in the face of (un)certainty; (3) overall satisfaction with genetic counseling; (4) decision\u2010making influenced by desire for information about their child's quality of life; (5) decision\u2010making influenced by reproductive options and family planning; and (6) importance of empathy, kindness, and clear communication from friends, family, and healthcare professionals. Many content categories show overlap to previous research. However, families in this cohort did not explicitly express negative opinions about waiting on results which is possibly explained by concurrently running multiple genetic testing modalities. Moreover, all participants mentioned positive experiences of the provided healthcare, partly because of swift multidisciplinary collaboration. This study highlights the value of pre\u2010test counseling by clinical geneticists and shows the need for close collaboration between feto\u2010maternal specialists, clinical geneticists, and laboratory specialists.<\/jats:p>","DOI":"10.1002\/jgc4.70187","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:51:27Z","timestamp":1772981487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experiences of Dutch parents undergoing prenatal genomic testing for fetal structural anomalies: A prospective qualitative analysis"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0557-7530","authenticated-orcid":false,"given":"Maayke A.","family":"de Koning","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center  Leiden The Netherlands"},{"name":"Neuroscience Research Australia (NeuRA)  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Long","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA)  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly E.","family":"Evans","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, UNSW Medicine and Health, Discipline of Pediatrics UNSW Sydney  Sydney New South Wales Australia"},{"name":"Behavioral Sciences Unit, Kids Cancer Centre Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-8807","authenticated-orcid":false,"given":"Lauren","family":"Kelada","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, UNSW Medicine and Health, Discipline of Pediatrics UNSW Sydney  Sydney New South Wales Australia"},{"name":"Behavioral Sciences Unit, Kids Cancer Centre Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-3267","authenticated-orcid":false,"given":"Gijs W. E.","family":"Santen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-5000","authenticated-orcid":false,"given":"Tony","family":"Roscioli","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA)  Sydney New South Wales Australia"},{"name":"Prince of Wales Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"NSW Health Pathology Randwick Genomics  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-6973","authenticated-orcid":false,"given":"Manon","family":"Suerink","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13871"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5102"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475\u20106773.2006.00684.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6692"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.70030"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100499\u20109"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5717"},{"key":"e_1_2_14_9_1","unstructured":"EUROCAT. (2020).European Surveillance of Congenital Anomalies (EUROCAT) cases and prevalence (per 10. 000 births) for all full member registries from 2008 to 2018. Prevalence tables."},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14006"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020224"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1311"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5729"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204158"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5195"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4635"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6153"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14010"},{"issue":"2","key":"e_1_2_14_19_1","first-page":"1","article-title":"Netherlands: Health system review","volume":"18","author":"Kroneman M.","year":"2016","journal-title":"Health Systems in Transition"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-30199-6"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13936"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)31940\u20108"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315617444"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6537"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6115"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6140"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.883225"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1401705"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)32042\u20107"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6056"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5172"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4916"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13814"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6444"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph21030299"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u201001025\u20105"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6112"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6157"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.11157\/fohpe.v23i1.544"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1644"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5332"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.70187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:32:12Z","timestamp":1781004732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jgc4.70187"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70187","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70187"}}