{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:03:34Z","timestamp":1781006614829,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Risk\u2010reducing mastectomy substantially reduces breast cancer risk in women at increased genetic or familial risk; however, it may have an impact on quality\u2010of\u2010life. The aim of this longitudinal study was to analyze differences in quality\u2010of\u2010life over time in women at increased risk of breast cancer who underwent risk\u2010reducing mastectomy. A total of 55 cisgender women at increased risk of breast cancer, due to\n                    <jats:italic>BRCA1\/2<\/jats:italic>\n                    pathogenic variants or a significant family history, participated in the study. Some of them had a prior diagnosis of breast cancer. Quality\u2010of\u2010life was assessed using EORTC Quality\u2010of\u2010Life Questionnaire Core 30 (QLQ\u2010C30) and the Breast Cancer\u2010Specific Module (BR23). Assessments were conducted 15\u201330\u2009days immediately before and 15\u201330\u2009days immediately after the risk\u2010reducing mastectomy, and at long\u2010term follow\u2010up. The follow\u2010up assessment ranged from 1 to 15\u2009years post\u2010surgery (mean\u2009=\u20095.24\u2009years). Changes over time were analyzed using repeated measures General Linear Models (GLM). Results indicated decreases in functional scales of quality\u2010of\u2010life and worsening of symptom scales following the risk\u2010reducing mastectomy. However, quality\u2010of\u2010life scores returned to baseline levels at long\u2010term follow\u2010up. Worries regarding future perspective decreased following surgery and continued to improve over time. Although risk\u2010reducing mastectomy was associated with short\u2010term deterioration in selected domains, findings indicate recovery and long\u2010term stabilization of quality\u2010of\u2010life. Additionally, risk\u2010reducing mastectomy appears to alleviate future\u2010oriented cancer concerns. This longitudinal evidence strengthens the basis for anticipatory guidance in genetic counseling and supports more balanced, evidence\u2010informed decision\u2010making.\n                  <\/jats:p>","DOI":"10.1002\/jgc4.70199","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:55:53Z","timestamp":1775480153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality\u2010of\u2010life after risk\u2010reducing mastectomy in women with increased risk of breast cancer: A longitudinal study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-893X","authenticated-orcid":false,"given":"S.","family":"Luque","sequence":"first","affiliation":[{"name":"Department of Personality, Assessment and Clinical Psychology, Faculty of Psychology Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-4094","authenticated-orcid":false,"given":"M. E.","family":"Olivares","sequence":"additional","affiliation":[{"name":"Department of Personality, Assessment and Clinical Psychology, Faculty of Psychology Universidad Complutense de Madrid  Madrid Spain"},{"name":"Breast Pathology Unit, Jos\u00e9 Botella Llusi\u00e1 Women\u2019s Health Institute Hospital Cl\u00ednico San Carlos  Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Brenes","sequence":"additional","affiliation":[{"name":"Breast Pathology Unit, Jos\u00e9 Botella Llusi\u00e1 Women\u2019s Health Institute Hospital Cl\u00ednico San Carlos  Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-5358","authenticated-orcid":false,"given":"M.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Breast Pathology Unit, Jos\u00e9 Botella Llusi\u00e1 Women\u2019s Health Institute Hospital Cl\u00ednico San Carlos  Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/JNCI\/85.5.365"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajm.AJM_21_18"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02711461\/METRICS"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2019.01.013"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002748.pub4"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-022-00244-y"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.5152\/ejbh.2019.4651"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.05.003"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-025-09364-2"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.003"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.06.003"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.0631"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13081357"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06081-7"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7112"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK-25-473450"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1465"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010017\u20105915\u20102"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CRITREVONC.2010.01.004"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-022-01950-5"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.6442"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1181-6"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.3424"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S303208"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.10.2756"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4604852"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJOG.2023.03.045"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:30:29Z","timestamp":1781004629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jgc4.70199"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70199","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70199"}}