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Although prior research suggests that healthcare decisions\u2014including risk assessment, screening, and treatment\u2014may differ between males and females, the influence of assigned sex at birth on HBOC testing decisions remains underexplored. Twenty\u2010eight participants (10 males, 18 females) considering HBOC testing were recruited from the Cancer Genetics Service at the National Cancer Centre Singapore. Semi\u2010structured interviews, informed by literature review and expert input, were conducted, and a codebook thematic analysis was applied to identify factors influencing testing decisions, with attention to differences between males and females. Five major themes were identified in decision\u2010making: personal health perceptions and psychological readiness; family influences on decision\u2010making; seeking support amid uncertainty; clinical expectations of genetic testing; and system\u2010level barriers to accessing genetic services. Male participants' decisions were shaped primarily by family and clinical support and psychosocial needs, whereas female participants' decisions were influenced by cancer status and social factors, with greater informational needs and misconceptions. HBOC testing decisions reflect sex\u2010specific needs, with males demonstrating greater psychosocial and clinical support requirements and females expressing higher informational needs. These findings underscore the importance of tailoring genetic counseling to sex\u2010specific considerations while ensuring individualized support for all patients.<\/jats:p>","DOI":"10.1002\/jgc4.70247","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:27:18Z","timestamp":1781530038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding shared and sex\u2010specific considerations in hereditary breast and ovarian cancer (\n                    <scp>HBOC<\/scp>\n                    ) testing decision\u2010making in Singapore"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-3518","authenticated-orcid":false,"given":"Jeanette","family":"Yuen","sequence":"first","affiliation":[{"name":"Cancer Genetics Service, Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-5779","authenticated-orcid":false,"given":"Ziyang","family":"Chua","sequence":"additional","affiliation":[{"name":"Cancer Genetics Service, Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khai Shin Alva","family":"Lim","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayhan Erlangga","family":"Rahadian","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Diana Binte","family":"Ishak","sequence":"additional","affiliation":[{"name":"Cancer Genetics Service, Division of Medical 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Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-3627","authenticated-orcid":false,"given":"Joanne","family":"Ngeow","sequence":"additional","affiliation":[{"name":"Cancer Genetics Service, Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore 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