{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:51:14Z","timestamp":1791478274861,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Population\u2010wide genomic screening (PWGS) offers a novel approach to identifying individuals at risk for hereditary cancer conditions such as Hereditary Breast and Ovarian Cancer (HBOC) Syndrome and Lynch Syndrome (LS). However, limited data exist on patient experiences and clinical outcomes following result disclosure. This study evaluated participant data from In Our DNA SC, a PWGS initiative offering free, CLIA\u2010certified genomic screening and genetic counseling. We analyzed survey and electronic medical record data of participants who received a clinically actionable result for HBOC or LS and who agreed to post\u2010test genetic counseling. Surveys were administered at three time points: pre\u2010counseling, 30\u2010days post\u2010counseling, and 6\u2010months post\u2010counseling. Of 260 invited, 52 participants completed the full survey series. Over half of participants (55.5%) reported being surprised by their genetic test result. Overall satisfaction with the return of results was high (mean &gt;\u20094.5\/5). Most emotional and cognitive responses did not differ significantly between groups, however, participants with LS were significantly more likely to report feeling calm\/comfortable, whereas participants with HBOC reported thinking about their results more often. Most participants engaged in follow\u2010up risk management: 80.8% discussed results with providers, 69.2% completed screening, and 51.9% were referred to specialists. Overall, findings support the feasibility and acceptability of PWGS in unselected populations. Future research should investigate the need for tailored support and strategies to reduce attrition to guide implementation of subsequent PWGS initiatives.<\/jats:p>","DOI":"10.1002\/jgc4.70274","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:01:22Z","timestamp":1787209282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population Genomic Screening for Hereditary Cancer Risk: Patient Experience, Perceptions, and Downstream Clinical Outcomes"],"prefix":"10.1002","volume":"35","author":[{"given":"Sarah","family":"English","sequence":"first","affiliation":[{"name":"College of Health Professions Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Malphrus","sequence":"additional","affiliation":[{"name":"College of Health Professions Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomics Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Judge","sequence":"additional","affiliation":[{"name":"College of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8334-6192","authenticated-orcid":false,"given":"Ingrid","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Implementation Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-3529","authenticated-orcid":false,"given":"Caitlin G.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Implementation Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2023.01.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1775"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.01.004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091511"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100876\u20104"},{"key":"e_1_2_12_7_1","unstructured":"Centers for Disease Control and Prevention.2014.\u201cTier 1 Genomics Applications and Their Importance to Public Health.\u201dhttps:\/\/archive.cdc.gov\/www.cdc.gov\/genomics\/implementation\/toolkit\/tier1.htm."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23686"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/m22\u20100846"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10010007"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2020.0275"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12121943"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010023\u201001470\u20101"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1166238"}],"container-title":["Journal of Genetic 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