{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:08:31Z","timestamp":1790251711104,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The expanding use of whole genome sequencing (WGS) and whole exome sequencing (WES) underscores the need to better understand the psychosocial impact of receiving a broader range of potential results than those generated by other types of genetic testing. This systematic review aimed to provide a comprehensive assessment of the psychosocial impact of WGS and WES testing in adult populations. An electronic literature search was conducted to identify studies published up to July 2025. Quantitative and qualitative studies involving adult population, published in English, and examining the psychosocial impact of WES and WGS test results were included in the analysis. The analysis included 45 studies (27 quantitative, 11 qualitative, 7 mixed\u2010methods). Findings were organized into four categories: positive experiences, negative experiences, uncertainty and results sharing. Positive experiences were common, with participants reporting satisfaction from gaining greater insight into their health; negative experiences were also frequently reported, but were typically of low intensity. Feelings of uncertainty were less present among individuals who received genetic counseling. Sharing of test results was widespread, with participants demonstrating a good understanding of the implications for both themselves and others. this systematic review provides an overview of the existing literature exploring the psychosocial impact of receiving WGS and WES results in the adult population. Overall, the findings indicate that the benefits generally outweigh the potential risks of psychological distress, and that sharing of results is common. However, further qualitative and longitudinal research with larger and more diverse samples, as well as more nuanced and sensitive instruments, are needed to identify individual differences in responses that will help inform the development of appropriate models of care.<\/jats:p>","DOI":"10.1002\/jgc4.70291","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:34:47Z","timestamp":1790249687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Psychosocial Impact of Receiving Whole Genome and Whole Exome Sequencing Results in Adults: A Systematic Review"],"prefix":"10.1002","volume":"35","author":[{"given":"Monica","family":"Albu","sequence":"first","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-7547","authenticated-orcid":false,"given":"Andrada","family":"Ciuc\u0103","sequence":"additional","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-5076","authenticated-orcid":false,"given":"Ramona","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Psychology Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Science University of Manchester  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023741"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258\u2010025\u201000948\u2010x"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525\u2010022\u201000295\u2010z"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010024\u201001795\u2010w"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050322"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010021\u201000902\u20105"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318220aaba"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2025.101363"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.8049"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/po.17.00250"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100061\u20101"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg\u20102022\u2010108929"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278\u20106133.21.6.564"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513219"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525\u2010021\u201000236\u20102"},{"key":"e_1_2_16_18_1","unstructured":"Dolling H.2025.\u201cPsychosocial Impact of Paediatric Early Rapid Genomic Testing and Diagnosis: A Mixed Methods Study of Parental Adjustment Adaptation Risk and Resilience [Apollo \u2010 University of Cambridge Repository].\u201dhttps:\/\/doi.org\/10.17863\/CAM.121146."},{"key":"e_1_2_16_19_1","volume-title":"Discovering Statistics Using IBM SPSS Statistics: And Sex and Drugs and Rock \u201cN\u201d Roll","author":"Field A.","year":"2013"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3132"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181a2743e"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865\u2010021\u201000253\u20107"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000733"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100308\u2010x"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jlb\/lsx038"},{"key":"e_1_2_16_26_1","unstructured":"Hong Q. N. P.Pluye S.F\u00e0bregues et\u00a0al.2018.\u201cMixed Methods Appraisal Tool (MMAT) version 2018.\u201dRegistration of Copyright (#1148552) Canadian Intellectual Property Office Industry Canada."},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1772"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13220"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.133"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.009"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010018\u20100286\u20109"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.58"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u201000957\u20102"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100083\u20108"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2019.105820"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2024.101103"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038\u2010024\u201001314\u2010w"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010020\u20100694\u20109"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.484"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104733.2007.00259.x"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010022\u201001065\u20102"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1096"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2020.113147"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100622\u2010y"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.176"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2021.04.026"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.223"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100565\u20103"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010018\u20100294\u2010z"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gimo.2024.101463"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.178"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.203"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.07.018"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010021\u201000834\u20109"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100806\u20105"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12433"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.12460"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.135"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271\u2010021\u201000558\u20104"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100906\u20102"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.88"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010018\u20100311\u20103"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atg.2016.01.008"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibz111"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17\u20100188"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100172\u2010x"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/17410541.2025.2476392"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37262"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010019\u20100619\u20109"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.70291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:34:50Z","timestamp":1790249690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jgc4.70291"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70291","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70291"}}