{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:50:15Z","timestamp":1791546615931,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n A prenatal diagnosis of Turner syndrome (TS) presents expectant parents with complex and emotionally demanding decisions under conditions of uncertainty. However, there is limited insight into how parents interpret and integrate medical information, personal experiences, and values during this process. This qualitative study explores how parents who chose to continue a pregnancy following a prenatal TS diagnosis experienced and navigated decision\u2010making. The study was conducted within the Danish healthcare system between September 2024 and October 2025. During this period, we conducted 12 semi\u2010structured interviews with 19 parents of girls diagnosed prenatally with TS (seven joint interviews with both parents and five interviews with the mother only). Interviews were audio\u2010recorded, transcribed verbatim, and analyzed using reflexive thematic analysis. Across interviews, parents repeatedly returned to the question, \u201cHow serious is this?\u201d, and our analysis showed that decision\u2010making unfolded as a dynamic, evolving process rather than a single point of choice. This process was captured through five interrelated themes:\n The crisis of diagnosis<\/jats:italic>\n ;\n What parents bring into decision\u2010making<\/jats:italic>\n ;\n Contrasting images of Turner syndrome<\/jats:italic>\n ;\n What kind of life is possible?<\/jats:italic>\n ; and\n The turning point<\/jats:italic>\n . These themes illustrate how assessments of seriousness were shaped through an interplay of prior experiences, emerging attachment to the fetus, ultrasound findings, counseling encounters, and social responses. Over time, parents developed a more coherent understanding of the diagnosis, culminating in the decision to continue the pregnancy. In this way, decision\u2010making following a prenatal TS diagnosis extended beyond the evaluation of medical information and involved substantial interpretative and emotional work. Clinical encounters were most meaningful when information was contextualized and aligned with parents' concerns about everyday life and future possibilities. These findings reinforce the importance of prenatal counseling that integrates medical information with support for the interpretative and emotional work through which parents make sense of the diagnosis and navigate uncertainty.\n <\/jats:p>","DOI":"10.1002\/jgc4.70298","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:55:08Z","timestamp":1791543308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Qualitative Study of Parental Decision\u2010Making Following a Prenatal Diagnosis of Turner Syndrome: \u201cHow Serious Is\u00a0This?\u201d"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-9233","authenticated-orcid":false,"given":"Inger Lily Hjuler","family":"Dorf","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Endocrinology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-5780","authenticated-orcid":false,"given":"Stina","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital Aarhus Denmark"},{"name":"DEFACTUM \u2013 Public Health Research, Central Denmark Region Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-6600","authenticated-orcid":false,"given":"Christine Manich Bech","family":"Baggesgaard","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8379-4092","authenticated-orcid":false,"given":"Rune W.","family":"Naeraa","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-8049","authenticated-orcid":false,"given":"Casper P.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) Copenhagen University Hospital \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-4901","authenticated-orcid":false,"given":"Anne","family":"Skakkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10897-009-9275-3","article-title":"Parental Decisions Regarding a Prenatally Detected Fetal Chromosomal Abnormality and the Impact of Genetic Counseling: An Analysis of 38 Cases With Aneuploidy in Southeast Turkey","volume":"19","author":"Balkan M.","year":"2010","journal-title":"Journal of Genetic Counseling"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ajmg.c.31805","article-title":"The Epidemiology of Sex Chromosome Abnormalities","volume":"184","author":"Berglund A.","year":"2020","journal-title":"American Journal of Medical Genetics. 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