{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:51:43Z","timestamp":1791888703781,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We present a case of a woman who underwent a successful bone marrow transplant for beta\u2010thalassemia major and later gave birth to a child who is compound heterozygous with HBB c.93\u201021G&gt;A and HBB c.316\u2010106C&gt;G mutations to illustrate the critical gaps in reproductive risk assessment and genetic counseling. The prevalence of consanguinity, socioeconomic challenges, and the lack of a cohesive genetics health system in a thalassemia\u2010endemic country all contribute to poor implementation of genetic care. Strengthening the education of healthcare practitioners, implementing centralized medical record systems, and expanding access to genetic services are becoming increasingly fundamental for improving genetic health care delivery across the Middle East and North Africa region.<\/jats:p>","DOI":"10.1002\/jgc4.70306","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:30:06Z","timestamp":1791887406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Child With \u03b2\u2010Thalassemia Major Born Following Hematopoietic Stem Cell Transplantation in the Mother: A Case Supporting the Expansion of Genetic Counseling Services in Lebanon and the Middle East"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9992-0768","authenticated-orcid":false,"given":"Roba","family":"El Zibaoui","sequence":"first","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-3452","authenticated-orcid":false,"given":"Soha","family":"Yazbek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Faculty of Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Abboud","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3109\/03630269.2014.939279","article-title":"Preventing Thalassemia in Lebanon: Successes and Challenges in a Developing Country","volume":"38","author":"Abi Saad M.","year":"2014","journal-title":"Hemoglobin"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s10897-015-9839-3","article-title":"Knowledge, Attitudes, and Practice Regarding Genetic Testing and Genetic Counselors in Jordan: A Population\u2010Based Survey","volume":"24","author":"Ahram M.","year":"2015","journal-title":"Journal of Genetic Counseling"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/hematolrep17050048"},{"key":"e_1_2_12_5_1","volume-title":"Prevention of Thalassaemias and Other Haemoglobin Disorders: Volume 1: Principles","author":"Angastiniotis M.","year":"2013"},{"issue":"2","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/03630269.2024.2338850","article-title":"Severe Transfusion\u2010Dependent Thalassemia in Compound Heterozygote Palestinian Siblings With Two \u03b1\u2010Globin Gene Defects, Hb Taybe D HBA1: C. 119_121delCCA Mutation and HBA2: C.* 94A> G Mutation","volume":"48","author":"Assaf N.","year":"2024","journal-title":"Hemoglobin"},{"issue":"4","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1017\/S0021932009003290","article-title":"Consanguinity in Lebanon: Prevalence, Distribution and Determinants","volume":"41","author":"Barbour B.","year":"2009","journal-title":"Journal of Biosocial Science"},{"key":"e_1_2_12_8_1","unstructured":"Bone Marrow Transplantation in \u03b2\u2010Thalassemia.2018.Thalassaemia International Federation.https:\/\/thalassemia.org\/files\/galleries\/TIF\u2010BMT\u2010v4_FINAL\u20100001.pdf."},{"key":"e_1_2_12_9_1","volume-title":"Research Square","author":"Chouery E.","year":"2024"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.70227"},{"issue":"6","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/03630269.2021.1920975","article-title":"The Spectrum of \u03b2\u2010Thalassemia Mutations in the Population Migration in Lebanon: A 6\u2010Year Retrospective Study","volume":"45","author":"Farra C.","year":"2021","journal-title":"Hemoglobin"},{"issue":"1","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12687-023-00633-3","article-title":"Interventions Addressing Genetic Disease Burdens Within Selected Countries in the MENA Region: A Scoping Review","volume":"14","author":"Grant M.","year":"2023","journal-title":"Journal of Community Genetics"},{"issue":"2","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12687-012-0127-8","article-title":"Epidemiological Profile of Common Haemoglobinopathies in Arab Countries","volume":"4","author":"Hamamy H. A.","year":"2013","journal-title":"Journal of Community Genetics"},{"issue":"1","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12687-018-0364-6","article-title":"Primary Care Providers' Lived Experiences of Genetics in Practice","volume":"10","author":"Harding B.","year":"2019","journal-title":"Journal of Community Genetics"},{"issue":"21","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1182\/blood.V122.21.5505.5505","article-title":"Outcome of Bone Marrow Transplantation in Lebanese Children With \u03b2\u2010Thalassemia Major","volume":"122","author":"Inati A.","year":"2013","journal-title":"Blood"},{"issue":"4","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2257.2006.00792.x","article-title":"Beta\u2010Thalassemia: The Lebanese Experience","volume":"28","author":"Inati A.","year":"2006","journal-title":"Clinical and Laboratory Haematology"},{"issue":"1","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12909-024-05110-0","article-title":"Genetic Literacy Among Primary Care Physicians in a Resource\u2010Constrained Setting","volume":"24","author":"Karam P. 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T.","year":"2024","journal-title":"British Journal of Haematology"},{"issue":"5","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.3892\/mmr.2017.7476","article-title":"\u03b2\u2010Thalassemia Caused by Compound Heterozygous Mutations and Cured by Bone Marrow Transplantation: A Case Report","volume":"16","author":"Wu L.","year":"2017","journal-title":"Molecular Medicine Reports"},{"issue":"2","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/S2352-3026(23)00006-6","article-title":"Sickle Cell Disease Care in Lebanon: Resource\u2010Constrained and Humanitarian Crisis Adaptations","volume":"10","author":"Yazbek S.","year":"2023","journal-title":"Lancet Haematology"}],"container-title":["Journal of Genetic Counseling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgc4.70306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgc4.70306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:30:10Z","timestamp":1791887410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgc4.70306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jgc4.70306"],"URL":"https:\/\/doi.org\/10.1002\/jgc4.70306","archive":["Portico"],"relation":{},"ISSN":["1059-7700","1573-3599"],"issn-type":[{"value":"1059-7700","type":"print"},{"value":"1573-3599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70306"}}