{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T13:51:49Z","timestamp":1720101109361},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After the A\/H1N1 influenza pandemic in 2009, two new drugs against the influenza virus, laninamivir and peramivir, were released in 2010 in Japan. We investigated the current usage and effectiveness of influenza medications and factors related to the time taken to alleviate fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with influenza during the 2012\u20102013 season in Osaka Prefecture answered a postcard questionnaire that collected data regarding their demographic characteristics, flu vaccination status, symptoms, prescribed drugs, and drug\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of laninamivir consistently increased over the 3\u2010year period and was prescribed at a similar rate as oseltamivir during the last year (39% and 45%, respectively). None of the neuraminidase inhibitors had a significant effect on the fever or other symptoms of influenza infection (<jats:italic>P<\/jats:italic>=.59 and <jats:italic>P<\/jats:italic>=.70, respectively). Vaccinated influenza patients experienced fever for a significantly longer duration than the nonvaccinated patients (<jats:italic>P<\/jats:italic>=.04). However, multivariate analysis showed that only influenza virus type, but not vaccination status, was related to the alleviation of fever within 2\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant differences of effects on fever and symptoms among neuraminidase inhibitors. Virus type was only related to the alleviation of fever.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.109","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T08:06:43Z","timestamp":1498032403000},"page":"386-392","source":"Crossref","is-referenced-by-count":5,"title":["Current usage and effectiveness of influenza medications and factors regarding the time taken to alleviate fever based on postcard questionnaire survey"],"prefix":"10.1002","volume":"18","author":[{"given":"Yoshihiro","family":"Tochino","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Fujioka Pediatric Clinic  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Sakazaki","sequence":"additional","affiliation":[{"name":"Sakazaki Child Clinic  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Ikuno","sequence":"additional","affiliation":[{"name":"Ikuno Internal Medicine Clinic  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Tochino","sequence":"additional","affiliation":[{"name":"Tochino ENT Clinic  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Shintaku","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"541","article-title":"A questionnaire study concerning the current status of influenza patients and their medication in Osaka Prefecture","volume":"60","author":"Tochino Y","year":"2012","journal-title":"Jpn J Chemother"},{"key":"e_1_2_8_3_1","first-page":"86","article-title":"A questionnaire study concerning the current status of influenza patients and their medication in the 2011\u201012 season","volume":"90","author":"Tochino Y","year":"2013","journal-title":"Jpn J Clin Exp Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2545"},{"key":"e_1_2_8_5_1","first-page":"354","article-title":"Estimated influenza vaccination rate in Japan","volume":"61","author":"Nobuhara H","year":"2014","journal-title":"Jpn Soc Public Health."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21144"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/429241"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/509925"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/656802"},{"key":"e_1_2_8_10_1","unstructured":"National Institute of Infectious Diseases Japan.Analysis of influenza virus isolates in 2012\u20102013 season Available fromhttp:\/\/www.nih.go.jp\/niid\/ja\/iasr-sp\/2257-related-articles\/related-articles-405\/4089-dj4051.html. Accessed November 24 2016."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.294"},{"key":"e_1_2_8_12_1","unstructured":"Ministry of Health Labour and Welfare the number of prescription of neuraminidase inhibitors in 2012\u201013 based on data furnished by pharmaceutical company. (in Japanese). Available fromhttp:\/\/www.mhlw.go.jp\/file\/05-Shingikai-10601000-Daijinkanboukouseikagakuka-Kouseikagakuka\/0000027857_1_1.pdf. Accessed November 24 2016."},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"The manual of influenza care for the 2013\u201014 season","volume":"28","author":"Kawai N","year":"2013","journal-title":"Jpn J Phys Assoc."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/505868"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgf2.109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:25:30Z","timestamp":1695572730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jgf2.109"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.109","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}