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Upon further investigation, anticardiolipin\/beta2\u2010glycoprotein I complex antibodies (CL\u2010\u03b22GPI) were detected, occasionally associated with syphilis. On day 14 of her fourth visit as an outpatient, serological tests confirmed the diagnosis, with newly appeared roseola on her palms and soles. She was in the transitional phase to secondary syphilis. Four months later, after successful treatment, her APTT was normalized with CL\u2010\u03b22GPI negative. Syphilis should be considered in patients with APTT prolongation.<\/jats:p>","DOI":"10.1002\/jgf2.210","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T13:37:39Z","timestamp":1538141859000},"page":"211-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of syphilis presenting with prolonged etiology\u2010unrevealed fever, accompanying activated partial thromboplastin time prolongation"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-1276","authenticated-orcid":false,"given":"Kazuhiro","family":"Yasuo","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine National Health organization Asahikawa Medical Center  Asahikawa\u2010City Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2169\/naika.96.2138"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.388"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.10.001"},{"key":"e_1_2_5_5_1","first-page":"425","article-title":"Anti\u2010beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala\u2010azar","volume":"19","author":"Santiago M","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316640912"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1172\/JCI0212337","article-title":"Bacterial induction of autoantibodies to beta2\u2010glycoprotein\u2010I accounts for the infectious etiology of antiphospholipid syndrome","volume":"109","author":"Blank M","year":"2002","journal-title":"J Clin Investig"},{"key":"e_1_2_5_8_1","first-page":"875","article-title":"Secondary pulmonary syphilis with pulmonary involvement","volume":"138","author":"Coleman DL","year":"1983","journal-title":"West J Med"},{"key":"e_1_2_5_9_1","unstructured":"CDC.Brief report: azithromycin treatment failures in syphilis infections\u2014San Francisco California 2002\u20132003.Atlanta GA:U.S. Department of Health and Human Services Centers for Disease Control and Prevention 2004;197\u20138. 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