{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:20:48Z","timestamp":1773487248408,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cervical lymphadenopathy is commonly seen in general practice, and its etiology is diverse. Establishing the diagnostic strategy for lymphadenopathy would be desirable to avoid overlooking neoplasms or other critical conditions. This study aims to identify the useful laboratory parameters for cervical lymphadenopathy that require clinical observation or intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The participants were outpatients presenting cervical swelling or cervical lymph node (LN) pain who consulted the General Internal Medicine department from 2010 to 2016. We evaluated the characteristics, physical findings, and laboratory parameters with final diagnoses by multivariate logistic regression analysis. We categorized the final diagnoses as \u201cClinical Intervention Required Group (CIRG)\u201d including necrotizing lymphadenitis, hematologic neoplasms, metastatic lymphadenopathy, tuberculous lymphadenitis, bacterial infectious diseases, infectious mononucleosis, autoimmune diseases, and other abnormal conditions or \u201cNo\u2010CIRG\u201d not requiring further clinical observation or intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 409 participants, with 130 (31.8%) diagnosed as belonging to the CIRG. There was an association between CIRG and various parameters: age \u226560\u00a0years old (adjusted odds ratio [AOR], 2.70; 95% confidence interval [CI], 1.48\u20104.90), having a referral (AOR, 1.83; 95% CI, 1.12\u20103.00), diameter of LN\u00a0\u2265\u00a02\u00a0cm (AOR, 1.91; 95% CI, 1.05\u20103.48), fixed LNs (AOR, 2.74; 95% CI, 1.02\u20107.37), and lactate dehydrogenase (LD) \u2265400\u00a0U\/L (AOR, 3.78; 95% CI, 1.46\u20109.77). Eighty\u2010two percent of LD\u00a0\u2265\u00a0400 cases in the CIRG were infectious mononucleosis or necrotizing lymphadenitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Besides the clinical indicators reported previously, we may apply an elevated LD level as a useful indicator of cervical lymphadenopathy that requires further clinical observation or intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.386","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T18:24:40Z","timestamp":1603045480000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of lactate dehydrogenase in differentiating abnormal cervical lymphadenopathy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-2512","authenticated-orcid":false,"given":"Naoko","family":"Kamiya","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Jichi Medical University Hospital Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-0782","authenticated-orcid":false,"given":"Yukiko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Jichi Medical University Hospital Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of General Medicine Shirakawa Satellite for Teaching and Research Fukushima Medical University Shirakawa\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Sagara","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Jichi Medical University Hospital Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Jichi Medical University Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Naka Mieno","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Center for Information Jichi Medical University Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-633X","authenticated-orcid":false,"given":"Kazuhiko","family":"Kotani","sequence":"additional","affiliation":[{"name":"Division of Community and Family Medicine Center for Community Medicine Jichi Medical University Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Jichi Medical University Hospital Shimotsuke\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"373","article-title":"Unexplained lymphadenopathy in family practice. 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