{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:19Z","timestamp":1747149679592,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatojugular reflux is a cardiac physical examination with a long history of use in heart failure diagnosis across many clinical settings. However, the development of new diagnostic methods has thrown the clinical role of hepatojugular reflux into question. Our meta\u2010analysis aimed to determine the diagnostic accuracy of hepatojugular reflux and assess its usefulness in diagnosing congestive heart failure among at\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This meta\u2010analysis of studies reporting diagnostic hepatojugular reflux values of patients at risk for congestive heart failure followed PRISMA guidelines. We searched MEDLINE, EMBASE, Web of Science, CENTRAL, and Google Scholar for eligible studies from inception through February 1, 2021. After QUADAS\u20102 quality assessment, we conducted data synthesis using the random effects model and a hierarchical summary receiver operating characteristic model. As an additional analysis, we sorted the studies by clinical setting and performed synthesis again. We submitted our protocol to PROSPERO (International Prospective Register of Systematic Reviews; ID No. CRD42020215004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search provided 4121 studies for evaluation. Seven studies and their 5195 participants were deemed eligible for synthesis. Clinical diagnosis was the most frequent reference standard. Bivariate random\u2010effects analysis found hepatojugular reflux sensitivity of 0.12, 95% confidence interval (CI) [0.07\u20130.19], and specificity of 0.96, 95% CI [0.95\u20130.97]. The DOR was 29.7, 95% CI [18.4\u201345.3]. The additional analysis of the emergency settings provided a sensitivity of 0.14, 95% CI [0.12\u20130.17] and specificity of 0.95, 95% CI [0.93\u20130.96].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis suggests that hepatojugular reflux has practical value for diagnosis of congestive heart failure with high specificity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.574","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T04:39:07Z","timestamp":1660970347000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical value of hepatojugular reflux on congestive heart failure: A meta\u2010analysis"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-0795","authenticated-orcid":false,"given":"Hiroyoshi","family":"Iwata","sequence":"first","affiliation":[{"name":"Clinical Research and Quality Management Center University of the Ryukyus Hospital  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-7149","authenticated-orcid":false,"given":"Yoshikazu","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Clinical Research and Quality Management Center University of the Ryukyus Hospital  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-731X","authenticated-orcid":false,"given":"Toshifumi","family":"Yodoshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Okinawa Chubu Hospital  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-9361","authenticated-orcid":false,"given":"Shinichiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Clinical Research and Quality Management Center University of the Ryukyus Hospital  Nishihara Japan"},{"name":"Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90940-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)28161-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.4.776"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2008.00954.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.09.011"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"National hospital discharge survey: 2007 summary","volume":"29","author":"Hall MJ","year":"2010","journal-title":"Natl Health Stat Rep"},{"issue":"108","key":"e_1_2_9_8_1","first-page":"1","article-title":"Hospitalization for congestive heart failure: United States, 2000\u20132010","author":"Hall MJ","year":"2012","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.25"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.6.610"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12878"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.6.1188"},{"key":"e_1_2_9_13_1","unstructured":"National Institute for Health Research.PROSPERO (International Prospective Register of Systematic Reviews). c. 2011\u20132021. 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