{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:34:53Z","timestamp":1753922093215},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report describes the case of a 65\u2010year\u2010old male who complained of muscular weakness of the legs with easy fatigability. Blood and imaging examinations showed positive anti\u2010acetylcholine receptor antibody and an anterior mediastinal tumor (probably a thymic cyst), suggesting the diagnosis of myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>). However, neurological and electrophysiological examinations suggested the diagnosis of Lambert\u2010Eaton myasthenic syndrome (<jats:styled-content style=\"fixed-case\">LEMS<\/jats:styled-content>). We searched repeatedly for malignant tumors. Small cell lung cancer (<jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content>) was found. Chemotherapy reduced the <jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content> and improved the patient's clinical symptoms. On the basis of an accurate diagnosis of <jats:styled-content style=\"fixed-case\">LEMS<\/jats:styled-content>, we were able to detect <jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content> and administer chemotherapy at an early stage. Anti\u2010P\/Q\u2010type voltage\u2010gated calcium channel antibody was negative. In our case, <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LEMS<\/jats:styled-content> overlap syndrome in addition to <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> should be differentiated. For the differentiation, the strict electrophysiological criteria of <jats:styled-content style=\"fixed-case\">LEMS<\/jats:styled-content> were useful.<\/jats:p>","DOI":"10.1002\/jgf2.66","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:29:47Z","timestamp":1492108187000},"page":"282-284","source":"Crossref","is-referenced-by-count":3,"title":["Lambert\u2010Eaton myasthenic syndrome with anti\u2010acetylcholine receptor antibody and anterior mediastinal tumor"],"prefix":"10.1002","volume":"18","author":[{"given":"Hideyuki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Neurology Japanese Red Cross Medical Center  Shibuya\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Ohtomo","sequence":"additional","affiliation":[{"name":"Department of Neurology Japanese Red Cross Medical Center  Shibuya\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugumi","family":"Akahori","sequence":"additional","affiliation":[{"name":"Department of Neurology Japanese Red Cross Medical Center  Shibuya\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideji","family":"Hashida","sequence":"additional","affiliation":[{"name":"Department of Neurology Japanese Red Cross Medical Center  Shibuya\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.14442\/jgfm.17.2_138"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.14442\/jgfm.17.3_211"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.93599"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20979"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.12.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2012.8.4.305"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgf2.66","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:03:25Z","timestamp":1695485005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/jgf2.66"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.66","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}