{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:35Z","timestamp":1786978055173,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to determine whether puncture sites for blood sampling and topical disinfectants are associated with rates of contaminated blood cultures in the emergency department (ED) of a single institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, ambidirectional cohort study of 548 consecutive patients \u226520\u2009years of age was performed in the ED of a university hospital in Japan over a 13\u2010month period. Pairs of blood samples were collected for aerobic and anaerobic cultures from patients in the ED. Physicians selected puncture sites and topical disinfectants according to their personal preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Potential contamination was identified in 110 of the 548 patients (20.1%). One hundred fourteen (20.8%) patients showed true\u2010positive results for bacteremia, and 324 (59.1%) patients showed true\u2010negative results. Multivariate analysis revealed more frequent contamination when puncture sites were disinfected with povidone\u2010iodine (PVI) than with alcohol\/chlorhexidine (ACHX) (adjusted risk difference, 19.1%; 95% confidence interval [CI]), 15.7\u201322.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In terms of blood collection sites, femoral and central venous (CV) catheter with PVI disinfection showed more frequent contamination than venous sites with ACHX (adjusted risk differences: 26.6%, 95% CI 21.3\u201331.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and 41.1%, 95% CI 22.2\u201359.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rates of contaminated blood cultures were significantly higher when blood was collected from the CV catheter or femoral sites with PVI as the topical disinfectant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgf2.667","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T02:39:10Z","timestamp":1702867150000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sites of blood collection and topical disinfectants associated with contaminated cultures: An ambidirectional cohort study"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-7031","authenticated-orcid":false,"given":"Koshi","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Osaka Medical and Pharmaceutical University  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-1195","authenticated-orcid":false,"given":"Daisuke","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Research and Development Center Osaka Medical and Pharmaceutical University  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Nursing Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanna","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Osaka Medical and Pharmaceutical University  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takasu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Osaka Medical and Pharmaceutical University  Takatsuki City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2018.12.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.09.033"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.06.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.10.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/650201"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.6.726"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062\u201005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.auec.2020.02.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085614\u20107"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90024-U"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032141"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.09.021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2011.05.026"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1043\/1543\u20102165(2005)129[1222:TIBCCA]2.0.CO;2"},{"issue":"5","key":"e_1_2_11_17_1","first-page":"438","article-title":"Clinical significance of potential contaminants in blood cultures among patients in a medical center","volume":"40","author":"Lee CC","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy158"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm223"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201000498\u2010x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010008\u20101046\u20103"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010006\u20100266\u20107"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mran.2023.100264"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02546\u201010"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.02.030"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/676533"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.01.030"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/665319"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00131"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2010.02868.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010017\u20101890\u2010z"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2006.12.034"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.8262"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2016.07.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12491"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211044367"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00877\u201010"},{"issue":"5","key":"e_1_2_11_38_1","first-page":"503","article-title":"Reduction in blood culture contamination rate by feedback to phlebotomists","volume":"121","author":"Gibb AP","year":"1997","journal-title":"Arch Pathol Lab Med"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:51:13Z","timestamp":1707799873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,17]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jgf2.667"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.667","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,17]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}