{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:52:44Z","timestamp":1779313964309,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) sequelae, also known as long COVID, can present with various symptoms. Among these symptoms, autonomic dysregulation, particularly postural orthostatic tachycardia syndrome (POTS), should be evaluated. However, previous studies on the treatment of POTS complicated by COVID\u201019 are lacking. Therefore, this study aimed to investigate the treatment course of long COVID complicated by POTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of patients who complained of fatigue and met the criteria for POTS diagnosis were reviewed. We evaluated the treatment days, methods and changes in fatigue score, changes in heart rate on the Schellong test, and social situation at the first and last visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two patients with long COVID complicated by POTS were followed up (16 males; median age: 28\u2009years). The follow\u2010up period was 159\u2009days, and the interval between COVID\u201019 onset and initial hospital attendance was 97\u2009days. Some patients responded to \u03b2\u2010blocker therapy. Many patients had psychiatric symptoms that required psychiatric intervention and selective serotonin reuptake inhibitor prescription. Changes in heart rate, performance status, and employment\/education status improved from the first to the last visit. These outcomes were believed to be because of the effects of various treatment interventions and spontaneous improvements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that the condition of 94% of patients with POTS complicated by long COVID will improve within 159\u2009days. Therefore, POTS evaluation should be considered when patients with long COVID complain of fatigue, and attention should be paid to psychological symptoms and the social context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.670","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T10:10:35Z","timestamp":1702980635000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of long COVID complicated by postural orthostatic tachycardia syndrome\u2014Case series research"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-3941","authenticated-orcid":false,"given":"Tomoya","family":"Tsuchida","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-6592","authenticated-orcid":false,"given":"Kosuke","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-7188","authenticated-orcid":false,"given":"Kohta","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Nakagama","sequence":"additional","affiliation":[{"name":"Department of Virology &amp; Parasitology, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"},{"name":"Research Center for Infectious Disease Sciences, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Virology &amp; Parasitology, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"},{"name":"Research Center for Infectious Disease Sciences, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehito","family":"Otsubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization (WHO) coronavirus (COVID\u201019) dashboard.2022.https:\/\/covid19.who.int. 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