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Although sulbactam\/ampicillin (SBT\/ABPC) is a widely used antibiotic, no prior case reports of its associated agranulocytosis were identified in our narrative literature review. We present a case of an 85\u2010year\u2010old man who developed agranulocytosis following SBT\/ABPC treatment for pressure ulcer infection and aspiration pneumonia, accompanied by a narrative literature review. Awareness of this condition, prompt discontinuation of the suspected agent, and close monitoring of total white blood cell counts are essential for early detection and management of this life\u2010threatening complication.<\/jats:p>","DOI":"10.1002\/jgf2.70027","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:30:28Z","timestamp":1745973028000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of idiosyncratic drug\u2010induced agranulocytosis because of sulbactam\/ampicillin"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3210-8023","authenticated-orcid":false,"given":"Kazuya","family":"Toda","sequence":"first","affiliation":[{"name":"Kamiichi Community Medical Support Unit Toyama University  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-5465","authenticated-orcid":false,"given":"Kaku","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Geriatrics &amp; Aging, Department of Medicine University of Rochester  Rochester New York USA"},{"name":"Department of General Medicine Toyama University Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-6562","authenticated-orcid":false,"given":"Moe","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of General Medicine Toyama University Hospital  Toyama Japan"},{"name":"Center for International Health SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Kawai","sequence":"additional","affiliation":[{"name":"Kamiichi Community Medical Support Unit Toyama University  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kamiichi General Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcw220"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.22541\/au.161839221.10007524\/v1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020975646"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010246788"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.727717"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"257","article-title":"Standardization of definitions and criteria for causality assessment of adverse drug reactions. 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