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This review explores the epidemiology, risk factors, screening strategies, and clinical manifestations of CKD within primary care settings. PCPs are integral in recognizing at\u2010risk populations, initiating timely screening through eGFR and albuminuria tests, and managing modifiable risk factors like hypertension and diabetes. The article discusses current guideline\u2010recommended pharmacologic therapies\u2014including RAAS inhibitors, SGLT2 inhibitors, GLP\u20101 receptor agonists, and non\u2010steroidal MRAs\u2014that slow disease progression. Lifestyle modifications and dietary interventions are emphasized as essential components of care. Additionally, the review outlines key indications for nephrology referral and the management of common CKD complications, such as anemia and mineral\u2010bone disorder. By embracing a proactive and multidisciplinary approach, PCPs can significantly influence CKD outcomes, reduce progression to end\u2010stage renal disease, and improve overall patient prognosis.<\/jats:p>","DOI":"10.1002\/jgf2.70054","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T06:09:15Z","timestamp":1753855755000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic kidney disease in the primary care setting: A narrative review"],"prefix":"10.1002","volume":"26","author":[{"given":"Faryal","family":"Safdar","sequence":"first","affiliation":[{"name":"Indiana University Fairbanks School of Public Health  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-1100","authenticated-orcid":false,"given":"Ahsan","family":"Aslam","sequence":"additional","affiliation":[{"name":"Indiana 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