{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:38:52Z","timestamp":1792474732207,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n Neisseria meningitidis<\/jats:italic>\n <\/jats:styled-content>\n can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan. In this case, a 35\u2010year\u2010old Japanese man presented with fever and a spreading skin rash. Blood culture identified\n \n N. meningitidis<\/jats:italic>\n <\/jats:styled-content>\n serogroup B. The patient was treated with antibiotics and fully recovered. Genetic analysis revealed a deficiency in complement component 7. This case highlights that IMD can occur in young, otherwise healthy individuals, some of whom may have underlying complement deficiency.\n <\/jats:p>","DOI":"10.1002\/jgf2.70075","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:16:30Z","timestamp":1760534190000},"page":"646-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-0646","authenticated-orcid":false,"given":"Hiroaki","family":"Nishioka","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-19740-y"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix143"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.74.720"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/naika.106.2603"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4076\/1757-1626-2-7103"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.12.016"},{"key":"e_1_2_12_8_1","unstructured":"Centers for Disease Control and Prevention (CDC) Meningococcal Disease \u201cMeningococcal Vaccination \u201d(2025) https:\/\/www.cdc.gov\/meningococcal\/vaccines\/index.html."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2408.180228"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-6-917"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1203-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16664"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04461-2"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.70075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgf2.70075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:54:46Z","timestamp":1792472086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jgf2.70075"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.70075","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}