{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T11:28:03Z","timestamp":1794310083578,"version":"4.9.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare inflammatory arthritis of older adults. We report a 92\u2010year\u2010old man who presented with fatigue and distal pitting edema, fulfilling the clinical features of RS3PE. Although corticosteroids are typically effective, he showed an incomplete response and relapsed despite dose escalation. Addition of methotrexate resulted in complete remission, with normalization of inflammatory markers. Elderly\u2010onset rheumatoid arthritis and paraneoplastic RS3PE were considered but were clinically unlikely. This case highlights that RS3PE can occur even in nonagenarians and may require disease\u2010modifying therapy when corticosteroid responsiveness is insufficient.<\/jats:p>","DOI":"10.1002\/jgf2.70098","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:04:44Z","timestamp":1767809084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Remitting Seronegative Symmetrical Synovitis With Pitting Edema in a Nonagenarian: An Atypical Clinical Course Requiring Methotrexate for Remission"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3944-9603","authenticated-orcid":false,"given":"Ken","family":"Sato","sequence":"first","affiliation":[{"name":"Toyota Municipal Okabayashi Clinic  Toyota Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","first-page":"741","article-title":"Paraneoplastic Remitting Seronegative Symmetrical Synovitis With Pitting Edema","volume":"17","author":"Cantini F.","year":"1999","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"404","article-title":"RS3PE Revisited: A Systematic Review and Meta\u2010Analysis of 331 Cases","volume":"34","author":"Karmacharya P.","year":"2016","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4239-19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-015-0525-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0556-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1192744"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2022.2046307"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.70.145"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.70098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgf2.70098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.70098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T11:04:32Z","timestamp":1794308672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.70098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jgf2.70098"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.70098","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70098"}}