{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:04:23Z","timestamp":1779786263378,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to examine the management of bisphosphonate (BP) therapy for osteoporosis in Japan, focusing on treatment duration, dual\u2010energy X\u2010ray absorptiometry (DXA) assessment status, therapy despite renal impairment, and history of atypical femoral fracture (AFF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, cross\u2010sectional study included 117 women inpatients aged \u2265\u200965\u2009years admitted to the Department of General Medicine at Nerima Hikarigaoka Hospital between October 2022 and September 2025 while receiving BP therapy. The primary outcome was the prevalence of ultra\u2010long\u2010term therapy (\u2265\u200910\u2009years oral or \u2265\u20096\u2009years intravenous). Secondary outcomes included long\u2010term therapy (\u2265\u20095\u2009years oral or \u2265\u20093\u2009years intravenous), unknown treatment duration, inadequate DXA assessment, therapy despite renal impairment (serum creatinine \u2265\u20091.5\u2009mg\/dL), and AFF history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 84.3\u2009\u00b1\u20097.1\u2009years. Ultra\u2010long\u2010term therapy occurred in 5.1% of patients, long\u2010term therapy in 23.1%, unknown treatment duration in 29.9%, and inadequate DXA assessment in 49.6%. Therapy despite renal impairment was noted in 6.8%, and one patient (0.8%) had AFF. Unknown treatment duration and inadequate DXA assessment were significantly more common in nonorthopedic care and in facility\u2010 or home\u2010based settings (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among older women in Japan, ultra\u2010long\u2010term BP therapy was rare; however, nearly half lacked adequate assessment of treatment duration or documented DXA evaluation. These findings reveal shortcomings in long\u2010term osteoporosis management, particularly in nonorthopedic and facility\u2010 or home\u2010based care settings. Standardized reassessment, appropriate DXA evaluation, and improved information sharing across care transitions are essential to optimize treatment quality and safety in an aging population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgf2.70126","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:14:22Z","timestamp":1778735662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of Bisphosphonate Therapy for Osteoporosis: A Single\u2010Center Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-6744","authenticated-orcid":false,"given":"Taku","family":"Harada","sequence":"first","affiliation":[{"name":"Department of General Medicine Nerima Hikarigaoka Hospital  Tokyo Japan"},{"name":"Department of Generalist Medicine Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2450-2546","authenticated-orcid":false,"given":"Shintaro","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Hospital General Medicine Tokyo Metropolitan Hiroo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30378-X"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae119"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2708"},{"key":"e_1_2_14_5_1","volume-title":"Guidelines for the Prevention and Treatment of Osteoporosis, 2025 Edition (in Japanese)","author":"Committee for the Preparation of the Guidelines for the Prevention and Treatment of Osteoporosis","year":"2025"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0533"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916525"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/909153"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05973-9"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10133002"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4885"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-086845"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050051"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01801-7"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S388160"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-07199-1"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_14_19_1","volume-title":"Guidelines for the Prevention and Treatment of Osteoporosis, 2015 Edition (in Japanese)","author":"Committee for the Preparation of the Guidelines for the Prevention and Treatment of Osteoporosis. 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