{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:10Z","timestamp":1790405950122,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Talaromyces marneffei<\/jats:italic>\n (TM) is an opportunistic infectious fungus, and more patients in HIV\u2010negative populations are infected with TM.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We reviewed the adult patients with\n TM<\/jats:styled-content>\n infections (\n TMIs<\/jats:styled-content>\n ) between November 1, 2020 and April 30, 2025. This single\u2010center retrospective study was conducted at a tertiary care hospital located in an urban area, eastern China. Patients with\n TMI<\/jats:styled-content>\n were divided into the following four groups: the\n HIV<\/jats:styled-content>\n group, the non\u2010\n HIV<\/jats:styled-content>\n with solid organ transplant (\n SOT<\/jats:styled-content>\n ) group, the non\u2010\n HIV<\/jats:styled-content>\n with stem cell transplantation (\n SCT<\/jats:styled-content>\n ) group, and the non\u2010\n HIV<\/jats:styled-content>\n with other factors group.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There were a total of 218 cases of talaromycosis: 165 in the HIV group, 16 in the non\u2010HIV with SOT group, 4 in the non\u2010HIV with SCT group, and 33 in the non\u2010HIV with other factors group. The number (proportion) of patients diagnosed through metagenomic next\u2010generation sequencing (mNGS) in the four groups was as follows: 51 (30.9%), 11 (68.8%), 2 (50.0%), and 25 (75.8%), respectively. The number (proportion) of patients who tested positive in both culture and mNGS was as follows: 19 (11.5%), 1 (6.3%), 0 (0.0%), and 1 (3.0%), respectively. Kaplan\u2013Meier estimates indicated that the patients in the non\u2010HIV with SCT group had the worst prognosis and those in the non\u2010HIV with other factors group had poorer prognosis than the patients in the HIV group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n TMI in patients who are HIV\u2010negative without SOT may have poorer prognosis. If talaromycosis is suspected, mNGS can be an important supplementary tool for confirming TMI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jgf2.70171","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:56:54Z","timestamp":1788778614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis of Patients Infected With\n Talaromyces marneffei<\/i>\n Across Various Risk Factors"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-3097","authenticated-orcid":false,"given":"JiaXin","family":"Wang","sequence":"first","affiliation":[{"name":"Kidney Disease Center, the First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaoMin","family":"Wang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, the First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-8533","authenticated-orcid":false,"given":"RenDing","family":"Wang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, the First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"200","article-title":"Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms","volume":"8","author":"Pruksaphon K.","year":"2022","journal-title":"Journal of Fungi (Basel, Switzerland)"},{"key":"e_1_2_9_3_1","unstructured":"United States Department of Health and Human Services \u201cTalaromycosis (Penicilliosis) Guidelines [EB\/OL] \u201d(2025) https:\/\/Clinicalinfo.hiv.gov."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/60.2.259"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"1045","article-title":"Clinical Characteristics and Mortality Predictors of HIV\u2010Associated Talaromycosis Across Endemic Southeast Asia: A Multicenter Cohort Study","volume":"81","author":"Cao C.","year":"2025","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"e_1_2_9_6_1","article-title":"Talaromycosis in Non\u2010HIV Immunocompromised Patients: A Systematic Review and Meta\u2010Analysis","volume":"37","author":"Hu Y.","year":"2024","journal-title":"Clinical Microbiology Reviews"},{"issue":"3","key":"e_1_2_9_7_1","article-title":"Talaromyces (Penicillium) Marneffei Infection in Non\u2010HIV\u2010Infected Patients","volume":"5","author":"Chan J. 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