{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:50:01Z","timestamp":1791363001082,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22K15678"],"award-info":[{"award-number":["22K15678"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008031","name":"Graduate School of Public Health, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding how patient trust in healthcare providers is related to readiness to deprescribe is essential for optimizing deprescribing. This study examined this association among older adults with polypharmacy in the U.S. and Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted cross\u2010sectional surveys involving Japanese older adults receiving care from a community hospital and primary care clinic (Kawasaki City,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009185) and American older adults recruited to a research registry within a university hospital system (Pittsburgh,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009107). Cohorts were recruited using similar inclusion criteria (5+ prescriptions, community\u2010resident, stable regimens, recent physician care, no dementia). Participants completed the 11\u2010item Patient Perceptions of Deprescribing short form to assess readiness to deprescribe (range 6\u201330) and trust in healthcare providers (range 5\u201325).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Greater trust in providers was associated with lower readiness to deprescribe across both samples, with no significant interaction by location. A higher number of medications was associated with greater readiness. Although U.S. participants had higher readiness (16.7 vs. 15.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and trust (21.9 vs. 19.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), the greater readiness observed among U.S. participants remained after adjustment for demographics and clinical characteristics (+2.45 points,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater trust in healthcare providers was consistently associated with lower readiness to deprescribe across both samples. Although U.S. older adults demonstrated greater readiness to deprescribe compared to Japanese counterparts, the association between trust and motivation was similar across settings. This finding suggests that how trust functions in patient\u2013provider relationships may be important for designing shared decision\u2010making interventions for deprescribing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgf2.70186","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:01:07Z","timestamp":1791360067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Trust in Healthcare Providers and Readiness to Deprescribe in Older Adults: A Cross\u2010Sectional Comparative Study in the United States and Japan"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-0588","authenticated-orcid":false,"given":"Kenya","family":"Ie","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"},{"name":"Department of General Internal Medicine Kawasaki Municipal Tama Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Linsky","sequence":"additional","affiliation":[{"name":"General Internal Medicine, Center for Health Optimization and Implementation Research (CHOIR), and New England Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"General Internal Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-9534","authenticated-orcid":false,"given":"Xinran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Education Peking University School of Public Health  Beijing China"},{"name":"Center for Healthy Aging Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina B.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Behavioral and Community Health Sciences University of Pittsburgh School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-1428","authenticated-orcid":false,"given":"Rie","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"},{"name":"Department of General Internal Medicine Kawasaki Municipal Tama Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-9956","authenticated-orcid":false,"given":"Steven M.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Behavioral and Community Health Sciences University of Pittsburgh School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(25)00044\u20101"},{"issue":"10469","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"P2314","DOI":"10.1016\/S0140-6736(24)01446-6","article-title":"The Burden of Diseases, Injuries, and Risk Factors by State in the USA, 1990\u20132021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"404","author":"GBD 2021 US Burden of Disease Collaborators","year":"2024","journal-title":"Lancet"},{"key":"e_1_2_12_4_1","volume-title":"Prescription Drug Use Among Adults Aged 40\u201379 in the United States and Canada","author":"Hales C. 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